ECM2

Protein identityUniProt · HPA

UniProt accession

O94769

Gene

ECM2

Ensembl

ENSG00000106823

Chromosome

9

Canonical length

699 aa

Protein class

Plasma proteins, Predicted secreted proteins

Subcellular location

Nucleoplasm,Nucleoli fibrillar center,Endoplasmic reticulum,Plasma membrane

Secretome location

Secreted to extracellular matrix

OverviewNCBI Gene

ECM2 encodes extracellular matrix protein 2, so named because it shares extensive similarity with known extracelluar matrix proteins. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

Canonical amino-acid sequenceUniProt

699 residues, UniProt reviewed canonical sequence.

>O94769|ECM2
     1  MKIAVLFCFF LLIIFQTDFG KNEEIPRKQR RKIYHRRLRK SSTSHKHRSN RQLGIQQTTV
    61  FTPVARLPIV NFDYSMEEKF ESFSSFPGVE SSYNVLPGKK GHCLVKGITM YNKAVWSPEP
   121  CTTCLCSDGR VLCDETMCHP QRCPQTVIPE GECCPVCSAT VSYSLLSGIA LNDRNEFSGD
   181  SSEQREPTNL LHKQLPPPQV GMDRIVRKEA LQSEEDEEVK EEDTEQKRET PESRNQGQLY
   241  SEGDSRGGDR KQRPGEERRL AHQQQRQGRE EEEDEEEEGE EGEEDEEDEE DPVRGDMFRM
   301  PSRSPLPAPP RGTLRLPSGC SLSYRTISCI NAMLTQIPPL TAPQITSLEL TGNSIASIPD
   361  EAFNGLPNLE RLDLSKNNIT SSGIGPKAFK LLKKLMRLNM DGNNLIQIPS QLPSTLEELK
   421  VNENNLQAID EESLSDLNQL VTLELEGNNL SEANVNPLAF KPLKSLAYLR LGKNKFRIIP
   481  QGLPGSIEEL YLENNQIEEI TEICFNHTRK INVIVLRYNK IEENRIAPLA WINQENLESI
   541  DLSYNKLYHV PSYLPKSLLH LVLLGNQIER IPGYVFGHME PGLEYLYLSF NKLADDGMDR
   601  VSFYGAYHSL RELFLDHNDL KSIPPGIQEM KALHFLRLNN NKIRNILPEE ICNAEEDDDS
   661  NLEHLHLENN YIKIREIPSY TFSCIRSYSS IVLKPQNIK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ECM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.41

Highest tissue expression

117 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.92

gnomAD pLI

0

gnomAD missense Z

0.7

DepMap mean gene effect

0.1

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell-matrix adhesion
• extracellular matrix organization
• positive regulation of cell-substrate adhesion

Molecular functions

• collagen V binding
• heparin binding
• integrin binding

Cellular components

• extracellular matrix
• interstitial matrix

Protein domainsUniProt · Pfam · InterPro

• VWFC domain
• Leucine-rich repeat
• Leucine-rich repeat, typical subtype
• Leucine rich repeat 4
• Leucine-rich repeat domain superfamily
• von Willebrand factor type C domain
• Leucine Rich repeats (2 copies)
• Leucine rich repeat
• Extracellular matrix protein 2

KeywordsUniProt

• Extracellular matrix
• Glycoprotein
• Leucine-rich repeat
• Repeat
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of ECM2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• MSL1
• RASSF1