Seroatlas · Human Serome Atlas

C14orf93

Uncharacterized protein C14orf93

Also known as: CN093_HUMAN, FLJ12154, RTFC

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H972
Gene: C14orf93
Ensembl: ENSG00000100802
Chromosome: 14
Canonical length: 538 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Subcellular location: Nucleoplasm,Plasma membrane
Secretome location: Secreted to blood

OverviewNCBI Gene

Enables RNA binding activity. Predicted to act upstream of or within cell differentiation and positive regulation of gene expression. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

538 residues, UniProt reviewed canonical sequence.

>Q9H972|C14orf93
     1  MSFSATILFS PPSGSEARCC CCACKSETNG GNTGSQGGNP PPSTPITVTG HGLAVQSSEQ
    61  LLHVIYQRVD KAVGLAEAAL GLARANNELL KRLQEEVGDL RQGKVSIPDE DGESRAHSSP
   121  PEEPGPLKES PGEAFKALSA VEEECDSVGS GVQVVIEELR QLGAASVGPG PLGFPATQRD
   181  MRLPGCTLAA SEAAPLLNPL VDDYVASEGA VQRVLVPAYA KQLSPATQLA IQRATPETGP
   241  ENGTKLPPPR PEDMLNAAAA LDSALEESGP GSTGELRHSL GLTVSPCRTR GSGQKNSRRK
   301  RDLVLSKLVH NVHNHITNDK RFNGSESIKS SWNISVVKFL LEKLKQELVT SPHNYTDKEL
   361  KGACVAYFLT KRREYRNSLN PFKGLKEKEE KKLRSRRYRL FANRSSIMRH FGPEDQRLWN
   421  DVTEELMSDE EDSLNEPGVW VARPPRFRAQ RLTELCYHLD ANSKHGTKAN RVYGPPSDRL
   481  PSAEAQLLPP ELYNPNFQEE EDEGGDENAP GSPSFDQPHK TCCPDLNSFI EIKVEKDE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C14orf93 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

skin: 17 nTPM
thymus: 15 nTPM
kidney: 12 nTPM
bone marrow: 12 nTPM
epididymis: 11 nTPM
thyroid gland: 11 nTPM

Single-cell type

neutrophils: 24 nCPM
tuft cells: 23 nCPM
neuroendocrine cells: 23 nCPM
thymic myoid cells: 20 nCPM
loop of henle epithelial cells: 20 nCPM
respiratory secretory cells: 19 nCPM

Immune cell

eosinophil: 23 nTPM
T-reg: 14 nTPM
non-classical monocyte: 13 nTPM
basophil: 12 nTPM
neutrophil: 11 nTPM
memory B-cell: 11 nTPM

Brain region

white matter: 16 nTPM
choroid plexus: 15 nTPM
medulla oblongata: 13 nTPM
basal ganglia: 13 nTPM
midbrain: 12 nTPM
thalamus: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.65
gnomAD pLI: 0.01
gnomAD missense Z: 1.18
DepMap mean gene effect: -0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

Protein of unknown function DUF4616
Domain of unknown function (DUF4616)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of C14orf93 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

MRFAP1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C14orf93 as an antibody target. Whether an autoantibody or antibody against C14orf93 could matter depends on whether native C14orf93 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C14orf93 is annotated as secreted, so native C14orf93 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label C14orf93 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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