Seroatlas · Human Serome Atlas

MAFIP

MaFF-interacting protein

Also known as: ENSG00000277400, MAFIP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WZ33
Gene
MAFIP
Ensembl
ENSG00000277400
Chromosome
Unmapped
Canonical length
124 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for MAFIP in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

124 residues, UniProt reviewed canonical sequence.

>Q8WZ33|MAFIP
     1  MLCPRAAFLV GSFHGVFPGP PASSHWEFWV PSTPVGAYFC PPQPQLTPPN TPKLVSEVEE
    61  LYKSITALRE KLLQAEQSLR NLKDIHMSLE KDVTAMTNSV FIDRQKCMAH RTCYPTILQL
   121  AGYQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAFIP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
5.3 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 5.3 nTPM
  • skin: 5 nTPM
  • esophagus: 4.9 nTPM
  • spleen: 4.9 nTPM
  • salivary gland: 4.7 nTPM
  • fallopian tube: 4.5 nTPM

Single-cell type

  • choroid plexus epithelial cells: 192 nCPM
  • oligodendrocytes: 127 nCPM
  • microglia: 116 nCPM
  • bergmann glia: 90 nCPM
  • oligodendrocyte progenitor cells: 89 nCPM
  • ependymal cells: 78 nCPM

Immune cell

  • plasmacytoid DC: 1.4 nTPM
  • T-reg: 0.9 nTPM
  • myeloid DC: 0.8 nTPM
  • NK-cell: 0.8 nTPM
  • naive CD4 T-cell: 0.6 nTPM
  • classical monocyte: 0.5 nTPM

Brain region

  • medulla oblongata: 20 nTPM
  • pons: 18 nTPM
  • white matter: 16 nTPM
  • cerebral cortex: 16 nTPM
  • midbrain: 16 nTPM
  • thalamus: 15 nTPM

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MAFIP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAFIP as an antibody target. Whether an autoantibody or antibody against MAFIP could matter depends on whether native MAFIP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAFIP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAFIP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MAFIP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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