Seroatlas · Human Serome Atlas

DNTTIP1

Deoxynucleotidyltransferase terminal-interacting protein 1

Also known as: C20orf167, dJ447F3.4, Tdif1, TDIF1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H147
Gene
DNTTIP1
Ensembl
ENSG00000101457
Chromosome
20
Canonical length
329 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Nucleoli rim,Mitotic chromosome
Quaternary structure
Homotrimer

OverviewNCBI Gene

DNTTIP1 binds DNA and enhances the activity of terminal deoxynucleotidyltransferase (TDT, or DNTT; MIM 187410), a DNA polymerase that catalyzes the polymerization of DNA in the absence of a DNA template (Yamashita et al., 2001 [PubMed 11473582]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

329 residues, UniProt reviewed canonical sequence.

>Q9H147|DNTTIP1
     1  MGATGDAEQP RGPSGAERGG LELGDAGAAG QLVLTNPWNI MIKHRQVQRR GRRSQMTTSF
    61  TDPAISMDLL RAVLQPSINE EIQTVFNKYM KFFQKAALNV RDNVGEEVDA EQLIQEACRS
   121  CLEQAKLLFS DGEKVIPRLT HELPGIKRGR QAEEECAHRG SPLPKKRKGR PPGHILSSDR
   181  AAAGMVWKPK SCEPIRREGP KWDPARLNES TTFVLGSRAN KALGMGGTRG RIYIKHPHLF
   241  KYAADPQDKH WLAEQHHMRA TGGKMAYLLI EEDIRDLAAS DDYRGCLDLK LEELKSFVLP
   301  SWMVEKMRKY METLRTENEH RAVEAPPQT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DNTTIP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
62 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 62 nTPM
  • bone marrow: 42 nTPM
  • urinary bladder: 37 nTPM
  • rectum: 36 nTPM
  • choroid plexus: 33 nTPM
  • colon: 33 nTPM

Single-cell type

  • neutrophils: 161 nCPM
  • goblet cells: 103 nCPM
  • megakaryocytes: 93 nCPM
  • late primary spermatocytes: 91 nCPM
  • hofbauer cells: 87 nCPM
  • cytotrophoblasts: 78 nCPM

Immune cell

  • neutrophil: 126 nTPM
  • eosinophil: 71 nTPM
  • classical monocyte: 51 nTPM
  • myeloid DC: 43 nTPM
  • intermediate monocyte: 22 nTPM
  • basophil: 17 nTPM

Brain region

  • midbrain: 22 nTPM
  • white matter: 22 nTPM
  • hypothalamus: 22 nTPM
  • choroid plexus: 21 nTPM
  • spinal cord: 20 nTPM
  • cerebral cortex: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.42
gnomAD pLI
0.73
gnomAD missense Z
2.12
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Terminal deoxynucleotidyltransferase-interacting factor 1
  • DNTTIP1, dimerisation domain
  • TdIF1, C-terminal
  • DNTTIP1 dimerisation domain
  • TdIF1, C-terminal

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DNTTIP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DNTTIP1 as an antibody target. Whether an autoantibody or antibody against DNTTIP1 could matter depends on whether native DNTTIP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DNTTIP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DNTTIP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DNTTIP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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