Seroatlas · Human Serome Atlas

CBY2

Protein chibby homolog 2

Also known as: CBY2_HUMAN, NURIT, SPERT

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NA61
Gene: CBY2
Ensembl: ENSG00000174015
Chromosome: 13
Canonical length: 448 aa
Protein class: Predicted intracellular proteins
Subcellular location: Calyx,Connecting piece,Mid piece,Principal piece,End piece,Annulus
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables identical protein binding activity. Predicted to be located in cytoplasmic vesicle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

448 residues, UniProt reviewed canonical sequence.

>Q8NA61|CBY2
     1  MSPLECSECF GDQLLHRTYT WQLTLHSRPN YTRKRDTRSE SLEIPISVVL PQRGTAEPFP
    61  RLHNLYSTPR CAQQAALPRL SRRMASQHSY PLNRFSSVPL DPMERPMSQA DLELDYNPPR
   121  VQLSDEMFVF QDGRWVNENC RLQSPYFSPS ASFHHKLHHK RLAKECMLQE ENKSLREENK
   181  ALREENRMLS KENKILQVFW EEHKASLGRE ESRAPSPLLH KDSASLEVVK KDHVALQVPR
   241  GKEDSTLQLL REENRALQQL LEQKQAYWAQ AEDTAAPAEE SKPAPSPHEE PCSPGLLQDQ
   301  GSGLSSRFEE PKGPPARQED SKELRALRKM VSNMSGPSGE EEAKVGPGLP DGCQPLQLLR
   361  EMRQALQALL KENRLLQEEN RTLQVLRAEH RGFQEENKAL WENNKLKLQQ KLVIDTVTEV
   421  TARMEMLIEE LYAFMPARSQ DPKKPSRV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CBY2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 93 nTPM

Expression across tissuesHPA

Tissue

testis: 93 nTPM
skin: 0.2 nTPM
fallopian tube: 0.1 nTPM
urinary bladder: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM

Single-cell type

late spermatids: 2,164 nCPM
early spermatids: 983 nCPM
late primary spermatocytes: 133 nCPM
oocytes: 18 nCPM
plasma cells: 14 nCPM
sertoli cells: 5.3 nCPM

Immune cell

T-reg: 0.7 nTPM
naive CD4 T-cell: 0.2 nTPM
MAIT T-cell: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

cerebral cortex: 0.1 nTPM
hippocampal formation: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
choroid plexus: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.09
gnomAD pLI: 0
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

identical protein binding

Cellular components

cytoplasmic vesicle

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CBY2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CBY2 as an antibody target. Whether an autoantibody or antibody against CBY2 could matter depends on whether native CBY2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CBY2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CBY2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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