Transcription factor Maf family
IPR024874
Definition
Maf transcription factors form a distinct subfamily of the basic leucine zipper (bZip) transcription factors PMID:17569705. Maf genes have been identified in a wide range of higher eukaryotes, including both vertebrate and invertebrate species. These proteins are unique among the bZip factors in that they contain a highly conserved extended homology region (EHR), or ancillary DNA binding region, in addition to a typical basic region, and both regions are involved in target DNA sequence recognition. Maf transcription factors regulate tissue-specific gene expression and cell-differentiation in a wide variety of tissues and are also involved in human diseases and oncogenic transformation. Tissue-specific expression invloves Maf binding to Maf-recognition elements (MAREs) in the regulatory regions of target genes, and interacting with other transcription factors.
7 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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