Seroatlas · Human Serome Atlas

NFE2L3

Nuclear factor erythroid 2-related factor 3

Also known as: NF2L3_HUMAN, Nrf3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y4A8
Gene: NFE2L3
Ensembl: ENSG00000050344
Chromosome: 7
Canonical length: 694 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Vesicles
Secretome location: Intracellular and membrane

OverviewNCBI Gene

This gene encodes a member of the cap 'n' collar basic-region leucine zipper family of transcription factors. The encoded protein heterodimerizes with small musculoaponeurotic fibrosarcoma factors to bind antioxidant response elements in target genes. This protein is a membrane bound glycoprotein that is targeted to the endoplasmic reticulum and the nuclear envelope. Pseudogenes of this gene are found on chromosomes 16, 17, and 18. [provided by RefSeq, Mar 2009]

Canonical amino-acid sequenceUniProt

694 residues, UniProt reviewed canonical sequence.

>Q9Y4A8|NFE2L3
     1  MKHLKRWWSA GGGLLHLTLL LSLAGLRVDL DLYLLLPPPT LLQDELLFLG GPASSAYALS
    61  PFSASGGWGR AGHLHPKGRE LDPAAPPEGQ LLREVRALGV PFVPRTSVDA WLVHSVAAGS
   121  ADEAHGLLGA AAASSTGGAG ASVDGGSQAV QGGGGDPRAA RSGPLDAGEE EKAPAEPTAQ
   181  VPDAGGCASE ENGVLREKHE AVDHSSQHEE NEERVSAQKE NSLQQNDDDE NKIAEKPDWE
   241  AEKTTESRNE RHLNGTDTSF SLEDLFQLLS SQPENSLEGI SLGDIPLPGS ISDGMNSSAH
   301  YHVNFSQAIS QDVNLHEAIL LCPNNTFRRD PTARTSQSQE PFLQLNSHTT NPEQTLPGTN
   361  LTGFLSPVDN HMRNLTSQDL LYDLDINIFD EINLMSLATE DNFDPIDVSQ LFDEPDSDSG
   421  LSLDSSHNNT SVIKSNSSHS VCDEGAIGYC TDHESSSHHD LEGAVGGYYP EPSKLCHLDQ
   481  SDSDFHGDLT FQHVFHNHTY HLQPTAPEST SEPFPWPGKS QKIRSRYLED TDRNLSRDEQ
   541  RAKALHIPFS VDEIVGMPVD SFNSMLSRYY LTDLQVSLIR DIRRRGKNKV AAQNCRKRKL
   601  DIILNLEDDV CNLQAKKETL KREQAQCNKA INIMKQKLHD LYHDIFSRLR DDQGRPVNPN
   661  HYALQCTHDG SILIVPKELV ASGHKKETQK GKRK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NFE2L3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

placenta: 32 nTPM
appendix: 10 nTPM
duodenum: 7.5 nTPM
lymph node: 7.5 nTPM
spleen: 7.2 nTPM
skin: 6.9 nTPM

Single-cell type

epicardial cells: 1,051 nCPM
syncytiotrophoblasts: 941 nCPM
cytotrophoblasts: 471 nCPM
paneth cells: 294 nCPM
breast secretory cells: 236 nCPM
migrating cytotrophoblasts: 216 nCPM

Immune cell

myeloid DC: 0.6 nTPM
T-reg: 0.6 nTPM
memory CD4 T-cell: 0.4 nTPM
MAIT T-cell: 0.3 nTPM
classical monocyte: 0.2 nTPM
intermediate monocyte: 0.2 nTPM

Brain region

cerebellum: 59 nTPM
cerebral cortex: 59 nTPM
white matter: 39 nTPM
pons: 33 nTPM
basal ganglia: 32 nTPM
medulla oblongata: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.31
gnomAD pLI: 0
gnomAD missense Z: -3.75
DepMap mean gene effect: -0.33
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NFE2L3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NFE2L3 as an antibody target. Whether an autoantibody or antibody against NFE2L3 could matter depends on whether native NFE2L3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NFE2L3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NFE2L3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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