Seroatlas · Human Serome Atlas

MACIR

Macrophage immunometabolism regulator

Also known as: C5orf30, FLJ25291, MACIR_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96GV9
Gene: MACIR
Ensembl: ENSG00000181751
Chromosome: 5
Canonical length: 206 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Actin filaments,Primary cilium,Cytosol

OverviewNCBI Gene

This gene, MACIR (previously known as C5orf30), has been associated with rheumatoid arthritis, functioning as a negative regulator of tissue damage and modulating the activity of synovial fibroblasts and macrophages. The encoded protein is highly conserved in vertebrate genomes but has no significant similarity to any other human protein. [provided by RefSeq, Dec 2019]

Canonical amino-acid sequenceUniProt

206 residues, UniProt reviewed canonical sequence.

>Q96GV9|MACIR
     1  MEVDINGESR STLTTLPFPG AEANSPGKAE AEKPRCSSTP CSPMRRTVSG YQILHMDSNY
    61  LVGFTTGEEL LKLAQKCTGG EESKAEAMPS LRSKQLDAGL ARSSRLYKTR SRYYQPYEIP
   121  AVNGRRRRRM PSSGDKCTKS LPYEPYKALH GPLPLCLLKG KRAHSKSLDY LNLDKMIKEP
   181  ADTEVLQYQL QHLTLRGDRV FARNNT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MACIR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 30 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 30 nTPM
colon: 21 nTPM
rectum: 20 nTPM
cerebral cortex: 20 nTPM
retina: 19 nTPM
spinal cord: 18 nTPM

Single-cell type

extravillous trophoblasts: 151 nCPM
platelets: 122 nCPM
neutrophils: 93 nCPM
neutrophil progenitors: 91 nCPM
colonocytes: 65 nCPM
megakaryocyte-erythroid progenitors: 63 nCPM

Immune cell

basophil: 38 nTPM
NK-cell: 7.3 nTPM
T-reg: 7.3 nTPM
eosinophil: 6.2 nTPM
memory B-cell: 4.2 nTPM
classical monocyte: 3.7 nTPM

Brain region

white matter: 45 nTPM
cerebral cortex: 32 nTPM
thalamus: 29 nTPM
basal ganglia: 29 nTPM
midbrain: 27 nTPM
spinal cord: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.89
gnomAD pLI: 0.43
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

UNC119-binding protein
UNC119-binding protein C5orf30 homologue

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MACIR in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MACIR as an antibody target. Whether an autoantibody or antibody against MACIR could matter depends on whether native MACIR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MACIR is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MACIR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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