Seroatlas · Human Serome Atlas

LGALS1

Galectin-1

Also known as: GBP, LEG1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P09382
Gene
LGALS1
Ensembl
ENSG00000100097
Chromosome
22
Canonical length
135 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Subcellular location
Cytosol
Secretome location
Secreted to blood
Quaternary structure
Homodimer

OverviewNCBI Gene

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

135 residues, UniProt reviewed canonical sequence.

>P09382|LGALS1
     1  MACGLVASNL NLKPGECLRV RGEVAPDAKS FVLNLGKDSN NLCLHFNPRF NAHGDANTIV
    61  CNSKDGGAWG TEQREAVFPF QPGSVAEVCI TFDQANLTVK LPDGYEFKFP NRLNLEAINY
   121  MAADGDFKIK CVAFD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LGALS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
2,499 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 2,499 nTPM
  • endometrium: 2,395 nTPM
  • cervix: 2,225 nTPM
  • adipose tissue: 2,019 nTPM
  • colon: 1,752 nTPM
  • fallopian tube: 1,628 nTPM

Single-cell type

  • decidual stromal cells: 10,329 nCPM
  • hepatic stellate cells: 6,726 nCPM
  • smooth muscle cells: 3,075 nCPM
  • hofbauer cells: 2,832 nCPM
  • ovarian stromal cells: 2,597 nCPM
  • extravillous trophoblasts: 2,292 nCPM

Immune cell

  • total PBMC: 4,676 nTPM
  • myeloid DC: 3,663 nTPM
  • classical monocyte: 3,059 nTPM
  • non-classical monocyte: 2,571 nTPM
  • intermediate monocyte: 2,327 nTPM
  • T-reg: 1,520 nTPM

Brain region

  • white matter: 834 nTPM
  • medulla oblongata: 684 nTPM
  • pons: 554 nTPM
  • thalamus: 543 nTPM
  • cerebellum: 498 nTPM
  • spinal cord: 464 nTPM

ReferencesPubMed · IEDB

Publications for LGALS1 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Reference: AutoantibodyPubMed

6 publications

Show 1 more

Reference: T cellIEDB

1 publication

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.55
gnomAD pLI
0
gnomAD missense Z
0.45
DepMap mean gene effect
0.13
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LGALS1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LGALS1 as an antibody target. Whether an autoantibody or antibody against LGALS1 could matter depends on whether native LGALS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LGALS1 is annotated as secreted, so native LGALS1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label LGALS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LGALS1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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