Seroatlas · Human Serome Atlas

CD7

T-cell antigen CD7

Also known as: CD7_HUMAN, GP40, LEU-9, Tp40, TP41

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P09564
Gene: CD7
Ensembl: ENSG00000173762
Chromosome: 17
Canonical length: 240 aa
Protein class: CD markers, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily. This protein is found on thymocytes and mature T cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

240 residues, UniProt reviewed canonical sequence.

>P09564|CD7
     1  MAGPPRLLLL PLLLALARGL PGALAAQEVQ QSPHCTTVPV GASVNITCST SGGLRGIYLR
    61  QLGPQPQDII YYEDGVVPTT DRRFRGRIDF SGSQDNLTIT MHRLQLSDTG TYTCQAITEV
   121  NVYGSGTLVL VTEEQSQGWH RCSDAPPRAS ALPAPPTGSA LPDPQTASAL PDPPAASALP
   181  AALAVISFLL GLGLGVACVL ARTQIKKLCS WRDKNSAACV VYEDMSHSRC NTLSSPNQYQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CD7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 51 nTPM

Expression across tissuesHPA

Tissue

spleen: 51 nTPM
thymus: 45 nTPM
lymph node: 35 nTPM
appendix: 31 nTPM
bone marrow: 27 nTPM
small intestine: 20 nTPM

Single-cell type

nk-cells: 774 nCPM
thymocytes: 373 nCPM
innate lymphoid cells: 333 nCPM
t-cells: 307 nCPM
pdcs: 26 nCPM
mast cells: 20 nCPM

Immune cell

NK-cell: 232 nTPM
naive CD8 T-cell: 72 nTPM
naive CD4 T-cell: 70 nTPM
gdT-cell: 67 nTPM
MAIT T-cell: 58 nTPM
memory CD8 T-cell: 49 nTPM

Brain region

medulla oblongata: 2.4 nTPM
cerebral cortex: 2.2 nTPM
spinal cord: 2 nTPM
white matter: 2 nTPM
hypothalamus: 1.7 nTPM
pons: 1.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.07
gnomAD pLI: 0.05
gnomAD missense Z: 0.54
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CD7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CD7 as an antibody target. Whether an autoantibody or antibody against CD7 could matter depends on whether native CD7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CD7 is annotated at the cell surface, where native CD7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CD7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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