Seroatlas · Human Serome Atlas

SSC5D

Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D

Also known as: FLJ35258, S5D-SRCRB, SRCRL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A1L4H1
Gene: SSC5D
Ensembl: ENSG00000179954
Chromosome: 19
Canonical length: 1573 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Subcellular location: Nucleoplasm,Cytosol
Secretome location: Secreted in other tissues

OverviewNCBI Gene

Predicted to enable fibronectin binding activity; laminin binding activity; and scavenger receptor activity. Predicted to be involved in defense response; detection of bacterial lipoprotein; and negative regulation of interleukin-8 production. Predicted to act upstream of or within regulation of interleukin-8 production. Predicted to be located in collagen-containing extracellular matrix. Predicted to be active in extracellular matrix and extracellular space. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

1573 residues, UniProt reviewed canonical sequence.

>A1L4H1|SSC5D
     1  MRVLACLLAA LVGIQAVERL RLADGPHGCA GRLEVWHGGR WGTVCDDGWD LRDAAVACRQ
    61  LGCGGALAAP GGAFFGEGAG PVWLSELACR GNEGQLGLCH HRGWKAHICS HEEDAGVVCA
   121  GQRVANSRDD STSPLDGAPW PGLLLELSPS TEEPLVTHAP RPAGNPQNAS RKKSPRPKQA
   181  KSTRAPLLTT GAPRQERLRL VSGPHRCAGR LEVWHGGRWG TVCDDGWDLR DAAVACRELG
   241  CGGALAAPGG ARFGPGAGPV WMDDVGCGGG EQALRDCPRS PWGRSNCDHS EDAGLVCTGP
   301  APRLRLADGP HGCAGRLEVW HGGRWGSVCD DAWDLRDAAV ACRELGCGGA LAAPGGAFFG
   361  EGSGPIILDD LRCRGNETAL RFCPARPWGQ HDCHHREDAG AVCDGMPLGY VPPTAPTDSN
   421  NSTPREAASR PPSTMTSQAP GTAGVSPPPA SPTVLWEPGP EAGSPQLRLV AGPSKCSGRL
   481  EVWHDQRWGT VCDDSWDMRD SAVVCRELGC GGPQQPDPAA GRFGWGAGPI WLDDVGCVGT
   541  EASLSDCPAA PWGKHNCAHN EDVGVTCTGP PGLDSISDPF SWSWIPGLGR DRDAWLPGEL
   601  ATKPSASVTA SVLEKTTTKA PGKMPKSTKK WVTKNAKRPT TQPPVMPTTK HSRAQSPPDL
   661  TSQTTAALTT EASRRPTSEF TRRPTTEAPQ RWTSHTTATL TPQAPRERTT KTMAMLTTQG
   721  PQEMTSESTI KSIPQASLEP SAEIPEGSPE SPKDPAPSPS VSTTGESGLF RVRLADGPNR
   781  CAGRLEVWHA GRWGTVCDDN WDLRDATVAC WELGCGKVRP RVGKTHYGPG TGPIWLDDMG
   841  CKGSEASLSD CPSGAWGKHN CDHEEDVGLT CTGYTDYDDY PPWTWDPTSR EDLAKGTTTA
   901  GVPGHTLPWR TTRRPGSSSP AIRRLPDTGS KDGYKLPWTW DTPSGRGLAE GTPTAGKLGP
   961  TLGAGTTRSP GSPPTLRVHG DTGSPRKPWP ERRPPRPAAT RTAPPTPSPG PSASPGPPGP
  1021  ALTSDSSREL TPHSALTSEA TSDAPDTSPP TPDPASRTNP DLILTSPDFA LSTPDSSVVP
  1081  ALTPEPSPTP LPTLPKELTS DPSTPSEVTS LSPTSEQVPE SDTTPDLDTT PYSSTVSEYS
  1141  RSPDPSPSPH PTTTPDPTMA PDPITTLNPT VTPHFPTTPH PTTTPHPTTI THSTMIPDPT
  1201  TTPQPFTTIT HSTMIPDPTT TPQPFTTMQP TTTPHSTTPH PTTTPHPTTI THSTMIPDPT
  1261  TTPQPFTTMQ PTTMPHPTTT PHPTTTPHPT TTPHPTTTPH PTMTPDPTTT PYPTTTPDPT
  1321  TTPHPTTPDP SSTPVITTVS LPTSLGTELS SPTLAPTVKP SLHPQLTFTA PAPHTSTSQI
  1381  PTLEPSPALE SSPSRSSTAT SMDPLSTEDF KPPRSQSPNL TPPPTHTPHS ASDLTVSPDP
  1441  LLSPTAHPLD HPPLDPLTLG PTPGQSPGPH GPCVAPTPPV RVMACEPPAL VELVAAVRDV
  1501  GGQLQRLTQV VEQERQERQA LLLGLTQLVE AARGLGQLGE AVKRLAEMAW TTSMPAPTTT
  1561  TPEEEERPLR GDV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SSC5D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 30 nTPM

Expression across tissuesHPA

Tissue

endometrium: 30 nTPM
colon: 28 nTPM
cervix: 21 nTPM
smooth muscle: 19 nTPM
fallopian tube: 18 nTPM
pituitary gland: 14 nTPM

Single-cell type

corticotrophs: 77 nCPM
hepatic stellate cells: 52 nCPM
fibro-adipogenic progenitors: 44 nCPM
decidual stromal cells: 34 nCPM
lactotrophs: 31 nCPM
fibroblasts: 30 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 10 nTPM
pons: 9.2 nTPM
medulla oblongata: 8.6 nTPM
thalamus: 8.1 nTPM
cerebellum: 6.9 nTPM
midbrain: 6.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.11
gnomAD pLI: 0
gnomAD missense Z: 1.54
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

defense response
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
innate immune response
negative regulation of interleukin-8 production
detection of bacterial lipoprotein

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SSC5D in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

LGALS1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SSC5D as an antibody target. Whether an autoantibody or antibody against SSC5D could matter depends on whether native SSC5D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SSC5D is annotated as secreted, so native SSC5D circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SSC5D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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