Seroatlas · Human Serome Atlas

THEMIS2

Protein THEMIS2

Also known as: C1orf38, ICB-1, THMS2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5TEJ8
Gene
THEMIS2
Ensembl
ENSG00000130775
Chromosome
1
Canonical length
643 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Predicted to be involved in T cell receptor signaling pathway and regulation of B cell activation. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

643 residues, UniProt reviewed canonical sequence.

>Q5TEJ8|THEMIS2
     1  MEPVPLQDFV RALDPASLPR VLRVCSGVYF EGSIYEISGN ECCLSTGDLI KVTQVRLQKV
    61  VCENPKTSQT MELAPNFQGY FTPLNTPQSY ETLEELVSAT TQSSKQLPTC FMSTHRIVTE
   121  GRVVTEDQLL MLEAVVMHLG IRSARCVLGM EGQQVILHLP LSQKGPFWTW EPSAPRTLLQ
   181  VLQDPALKDL VLTCPTLPWH SLILRPQYEI QAIMHMRRTI VKIPSTLEVD VEDVTASSRH
   241  VHFIKPLLLS EVLAWEGPFP LSMEILEVPE GRPIFLSPWV GSLQKGQRLC VYGLASPPWR
   301  VLASSKGRKV PRHFLVSGGY QGKLRRRPRE FPTAYDLLGA FQPGRPLRVV ATKDCEGERE
   361  ENPEFTSLAV GDRLEVLGPG QAHGAQGSDV DVLVCQRLSD QAGEDEEEEC KEEAESPERV
   421  LLPFHFPGSF VEEMSDSRRY SLADLTAQFS LPCEVKVVAK DTSHPTDPLT SFLGLRLEEK
   481  ITEPFLVVSL DSEPGMCFEI PPRWLDLTVV KAKGQPDLPE GSLPIATVEE LTDTFYYRLR
   541  KLPACEIQAP PPRPPKNQGL SKQRRHSSEG GVKSSQVLGL QQHARLPKPK AKTLPEFIKD
   601  GSSTYSKIPA HRKGHRPAKP QRQDLDDDEH DYEEILEQFQ KTI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against THEMIS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
203 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 203 nTPM
  • spleen: 118 nTPM
  • appendix: 69 nTPM
  • lymph node: 45 nTPM
  • lung: 43 nTPM
  • spinal cord: 33 nTPM

Single-cell type

  • neutrophils: 378 nCPM
  • monocytes: 194 nCPM
  • kupffer cells: 160 nCPM
  • pdcs: 156 nCPM
  • macrophages: 143 nCPM
  • cdc: 124 nCPM

Immune cell

  • neutrophil: 500 nTPM
  • non-classical monocyte: 457 nTPM
  • intermediate monocyte: 442 nTPM
  • classical monocyte: 404 nTPM
  • total PBMC: 381 nTPM
  • eosinophil: 342 nTPM

Brain region

  • white matter: 41 nTPM
  • medulla oblongata: 37 nTPM
  • pons: 30 nTPM
  • thalamus: 29 nTPM
  • hypothalamus: 25 nTPM
  • spinal cord: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.71
gnomAD pLI
0
gnomAD missense Z
1.24
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of THEMIS2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads THEMIS2 as an antibody target. Whether an autoantibody or antibody against THEMIS2 could matter depends on whether native THEMIS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

THEMIS2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label THEMIS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/THEMIS2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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