GOLGA6A

Protein identityUniProt · HPA

UniProt accession

Q9NYA3

Gene

GOLGA6A

Ensembl

ENSG00000159289

Chromosome

15

Canonical length

693 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Vesicles,Centrosome

OverviewNCBI Gene

The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. The protein encoded by this gene is a member of the golgin family of proteins, whose members localize to the Golgi. This gene is found in a large, low copy repeat sequence or duplicon that is found in multiple copies, that are greather than 90% similar, on chromosome 15. Duplicons are associated with deletions, inversions and other chromosome rearrangements that underlie genomic disease. The protein encoded by this gene is thought to be a functional golgin protein while the majority of the related copies of this gene are thought to be transcribed pseudogenes. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

693 residues, UniProt reviewed canonical sequence.

>Q9NYA3|GOLGA6A
     1  MWPQPYLPPH PMMLEESRQN KLAAAKKKLK EYQQRKSPGI PAGAKTKKKK TDSSPETTTS
    61  GGCHSPGDSQ YQELAVALES SSVTISQLNE NIESLKQQKK QVEHQLEEAK KTNNEIHKAQ
   121  MERLETINIL TLEKADLKTT LYHTKRAARH FEEESKDLAG RLQYSLQRIQ ELERALCAVS
   181  TQQQEEDRSS SCREAVLQRW LQQTIKERAL LNAHVTQVTE SLKQVQLERD EYAKHIKGER
   241  ARWQERMWKM SVEARTLKEE KKRDIHRIQE LERSLSELKN QMAEPPSLAP PAVTSVVEQL
   301  QDEAKHLRQE VEGLEGKLQS QVENNQALSL LSKEQKQRLQ EQEEMLREQE AQRVREQERL
   361  CEQNERLREQ QKTLQEQGER LRKQEQRLRK QEERLRKEEE RLQKQEKRLW DQEERLWKKE
   421  ERLQKQEERL ALSQNHKLDK QLAEPQCSFE DLNNEKKSAL QLEQQVKELQ EKLDEEHLEA
   481  ASHQNQQLET QLSLVALPGE GDGGQHLDSE EEEAPRPTPN IPEDLESREA TSSFMDLPKE
   541  KADGTEQVER RELGFVQPSG VTDGMRESFT VYESQGAVPN TRHQEMEDVI RLAQKEEEMK
   601  VKLLELQELV LPLVGNHEGH GKFLIAAQNP ADEPTPGAPA PQELGAAGEQ DVFYEVSLDN
   661  NVEPAPGAAR EGSPHDNPTV QQIVQLSPVM QDT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GOLGA6A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.57

Highest tissue expression

12 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.5

gnomAD pLI

0

gnomAD missense Z

-0.29

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• Golgi organization

Cellular components

• cis-Golgi network
• Golgi cis cisterna
• Golgi cisterna membrane

Protein domainsUniProt · Pfam · InterPro

• Golgin subfamily A
• Golgin subfamily A, conserved domain
• Putative golgin subfamily A member 2-like protein 5

KeywordsUniProt

• Coiled coil

InteractionsUniProt · HPA

Protein binding partners of GOLGA6A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• KCTD9