Seroatlas · Human Serome Atlas

RSPH3

Radial spoke head protein 3 homolog

Also known as: RSPH3_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86UC2
Gene: RSPH3
Canonical length: 560 aa
Protein class: Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for RSPH3 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

560 residues, UniProt reviewed canonical sequence.

>Q86UC2|RSPH3
     1  MTVKPAKAAS LARNLAKRRR TYLGGAAGRS QEPEVPCAAV LPGKPGDRNC PEFPPPDRTL
    61  GCWATDAAPA AGLCGAGSEP SIAPTSCAGN LPSRPPPLLS PLLASRNPCP WHYLHLSGSH
   121  NTLAPTCFKA KLHRKRGSQP PDMASALTDR TSRAPSTYTY TSRPRALPCQ RSRYRDSLTQ
   181  PDEEPMHYGN IMYDRRVIRG NTYALQTGPL LGRPDSLELQ RQREARKRAL ARKQAQEQLR
   241  PQTPEPVEGR KHVDVQTELY LEEIADRIIE VDMECQTDAF LDRPPTPLFI PAKTGKDVAT
   301  QILEGELFDF DLEVKPVLEV LVGKTIEQSL LEVMEEEELA NLRASQREYE ELRNSERAEV
   361  QRLEEQERRH REEKERRKKQ QWEIMHKHNE TSQKIAARAF AQRYLADLLP SVFGSLRDSG
   421  YFYDPIERDI EIGFLPWLMN EVEKTMEYSM VGRTVLDMLI REVVEKRLCM YEHGEDTHQS
   481  PEPEDEPGGP GAMTESLEAS EFLEQSMSQT RELLLDGGYL QRTTYDRRSS QERKFMEERE
   541  LLGQDEETAM RKSLGEEELS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RSPH3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 12 nTPM
testis: 12 nTPM
choroid plexus: 8.4 nTPM
thyroid gland: 7 nTPM
esophagus: 6.2 nTPM
retina: 6.1 nTPM

Single-cell type

respiratory ciliated cells: 313 nCPM
endometrial ciliated cells: 206 nCPM
esophageal apical cells: 188 nCPM
ependymal cells: 176 nCPM
choroid plexus epithelial cells: 161 nCPM
late primary spermatocytes: 151 nCPM

Immune cell

neutrophil: 11 nTPM
non-classical monocyte: 7 nTPM
plasmacytoid DC: 4.6 nTPM
classical monocyte: 4 nTPM
myeloid DC: 4 nTPM
intermediate monocyte: 3 nTPM

Brain region

choroid plexus: 41 nTPM
cerebral cortex: 20 nTPM
midbrain: 15 nTPM
medulla oblongata: 14 nTPM
hippocampal formation: 14 nTPM
spinal cord: 13 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RSPH3.

Disease | AllUniProt

Conditions RSPH3 is implicated in, by any mechanism.

Ciliary dyskinesia, primary, 32 (CILD32) MIM:616481

Disease | GeneticClinVar

30 pathogenic / likely-pathogenic of 357 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Primary ciliary dyskinesia 32
RSPH3-related disorder
Clear cell carcinoma of kidney
Colon adenocarcinoma

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.93
gnomAD pLI: 0
gnomAD missense Z: 0.07
DepMap mean gene effect: -0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Radial spoke 3
Radial spoke protein 3

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RSPH3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RSPH3 as an antibody target. Whether an autoantibody or antibody against RSPH3 could matter depends on whether native RSPH3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RSPH3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RSPH3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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