Seroatlas · Human Serome Atlas

INTS2

Integrator complex subunit 2

Also known as: INT2, INT2_HUMAN, KIAA1287

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H0H0
Gene: INTS2
Ensembl: ENSG00000108506
Chromosome: 17
Canonical length: 1204 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

INTS2 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

1204 residues, UniProt reviewed canonical sequence.

>Q9H0H0|INTS2
     1  MKDQQTVIMT ECTSLQFVSP FAFEAMQKVD VVCLASLSDP ELRLLLPCLV RMALCAPADQ
    61  SQSWAQDKKL ILRLLSGVEA VNSIVALLSV DFHALEQDAS KEQQLRHKLG GGSGESILVS
   121  QLQHGLTLEF EHSDSPRRLR LVLSELLAIM NKVSESNGEF FFKSSELFES PVYLEEAADV
   181  LCILQAELPS LLPIVDVAEA LLHVRNGAWF LCLLVANVPD SFNEVCRGLI KNGERQDEES
   241  LGGRRRTDAL RFLCKMNPSQ ALKVRGMVVE ECHLPGLGVA LTLDHTKNEA CEDGVSDLVC
   301  FVSGLLLGTN AKVRTWFGTF IRNGQQRKRE TSSSVLWQMR RQLLLELMGI LPTVRSTRIV
   361  EEADVDMEPN VSVYSGLKEE HVVKASALLR LYCALMGIAG LKPTEEEAEQ LLQLMTSRPP
   421  ATPAGVRFVS LSFCMLLAFS TLVSTPEQEQ LMVVWLSWMI KEEAYFESTS GVSASFGEML
   481  LLVAMYFHSN QLSAIIDLVC STLGMKIVIK PSSLSRMKTI FTQEIFTEQV VTAHAVRVPV
   541  TSNLSANITG FLPIHCIYQL LRSRSFTKHK VSIKDWIYRQ LCETSTPLHP QLLPLIDVYI
   601  NSILTPASKS NPEATNQPVT EQEILNIFQG VIGGDNIRLN QRFSITAQLL VLYYILSYEE
   661  ALLANTKTLA AMQRKPKSYS SSLMDQIPIK FLIRQAQGLQ QELGGLHSAL LRLLATNYPH
   721  LCIVDDWICE EEITGTDALL RRMLLTNNAK NHSPKQLQEA FSAVPVNNTQ VMQIIEHLTL
   781  LSASELIPYA EVLTSNMSQL LNSGVPRRIL QTVNKLWMVL NTVMPRRLWV MTVNALQPSI
   841  KFVRQQKYTQ NDLMIDPLIV LRCDQRVHRC PPLMDITLHM LNGYLLASKA YLSAHLKETE
   901  QDRPSQNNTI GLVGQTDAPE VTREELKNAL LAAQDSAAVQ ILLEICLPTE EEKANGVNPD
   961  SLLRNVQSVI TTSAPNKGME EGEDNLLCNL REVQCLICCL LHQMYIADPN IAKLVHFQGY
  1021  PCELLPLTVA GIPSMHICLD FIPELIAQPE LEKQIFAIQL LSHLCIQYAL PKSLSVARLA
  1081  VNVMGTLLTV LTQAKRYAFF MPTLPSLVSF CRAFPPLYED IMSLLIQIGQ VCASDVATQT
  1141  RDIDPIITRL QQIKEKPSGW SQICKDSSYK NGSRDTGSMD PDVQLCHCIE RTVIEIINMS
  1201  VSGI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against INTS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 5.4 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 5.4 nTPM
lymph node: 5 nTPM
tonsil: 5 nTPM
thymus: 4.5 nTPM
testis: 4.2 nTPM
retina: 4 nTPM

Single-cell type

myonuclei: 64 nCPM
retinal horizontal cells: 46 nCPM
cardiomyocytes: 46 nCPM
oligodendrocytes: 43 nCPM
monocyte progenitors: 42 nCPM
neutrophil progenitors: 38 nCPM

Immune cell

basophil: 2.1 nTPM
memory B-cell: 1.5 nTPM
MAIT T-cell: 1.4 nTPM
memory CD8 T-cell: 1.4 nTPM
naive CD8 T-cell: 1.4 nTPM
T-reg: 1.2 nTPM

Brain region

cerebellum: 16 nTPM
white matter: 15 nTPM
cerebral cortex: 14 nTPM
medulla oblongata: 13 nTPM
thalamus: 13 nTPM
basal ganglia: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.28
gnomAD pLI: 1
gnomAD missense Z: 2.26
DepMap mean gene effect: -1.03
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Integrator complex subunit 2, metazoa
Integrator complex subunit 2
Integrator complex subunit 2

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of INTS2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads INTS2 as an antibody target. Whether an autoantibody or antibody against INTS2 could matter depends on whether native INTS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

INTS2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label INTS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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