Seroatlas · Human Serome Atlas

INTS13

Integrator complex subunit 13

Also known as: ASUN, C12orf11, FLJ10637, INT13_HUMAN, Mat89Bb, NET48, SPATA30

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NVM9
Gene
INTS13
Ensembl
ENSG00000064102
Chromosome
12
Canonical length
706 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear bodies,Vesicles

OverviewNCBI Gene

Involved in regulation of mitotic cell cycle. Acts upstream of or within centrosome localization; mitotic spindle organization; and protein localization to nuclear envelope. Located in cytoplasm and nuclear body. Part of integrator complex. Is active in nucleus. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

706 residues, UniProt reviewed canonical sequence.

>Q9NVM9|INTS13
     1  MKIFSESHKT VFVVDHCPYM AESCRQHVEF DMLVKNRTQG IIPLAPISKS LWTCSVESSM
    61  EYCRIMYDIF PFKKLVNFIV SDSGAHVLNS WTQEDQNLQE LMAALAAVGP PNPRADPECC
   121  SILHGLVAAV ETLCKITEYQ HEARTLLMEN AERVGNRGRI ICITNAKSDS HVRMLEDCVQ
   181  ETIHEHNKLA ANSDHLMQIQ KCELVLIHTY PVGEDSLVSD RSKKELSPVL TSEVHSVRAG
   241  RHLATKLNIL VQQHFDLAST TITNIPMKEE QHANTSANYD VELLHHKDAH VDFLKSGDSH
   301  LGGGSREGSF KETITLKWCT PRTNNIELHY CTGAYRISPV DVNSRPSSCL TNFLLNGRSV
   361  LLEQPRKSGS KVISHMLSSH GGEIFLHVLS SSRSILEDPP SISEGCGGRV TDYRITDFGE
   421  FMRENRLTPF LDPRYKIDGS LEVPLERAKD QLEKHTRYWP MIISQTTIFN MQAVVPLASV
   481  IVKESLTEED VLNCQKTIYN LVDMERKNDP LPISTVGTRG KGPKRDEQYR IMWNELETLV
   541  RAHINNSEKH QRVLECLMAC RSKPPEEEER KKRGRKREDK EDKSEKAVKD YEQEKSWQDS
   601  ERLKGILERG KEELAEAEII KDSPDSPEPP NKKPLVEMDE TPQVEKSKGP VSLLSLWSNR
   661  INTANSRKHQ EFAGRLNSVN NRAELYQHLK EENGMETTEN GKASRQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against INTS13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
33 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 33 nTPM
  • adrenal gland: 21 nTPM
  • retina: 20 nTPM
  • skeletal muscle: 18 nTPM
  • thymus: 17 nTPM
  • tongue: 17 nTPM

Single-cell type

  • parietal cells: 96 nCPM
  • oligodendrocytes: 53 nCPM
  • esophageal suprabasal cells: 42 nCPM
  • cone photoreceptor cells: 41 nCPM
  • esophageal basal cells: 39 nCPM
  • hematopoietic stem cells: 34 nCPM

Immune cell

  • T-reg: 28 nTPM
  • NK-cell: 26 nTPM
  • MAIT T-cell: 22 nTPM
  • memory CD4 T-cell: 18 nTPM
  • memory CD8 T-cell: 18 nTPM
  • naive CD8 T-cell: 16 nTPM

Brain region

  • white matter: 33 nTPM
  • medulla oblongata: 25 nTPM
  • spinal cord: 22 nTPM
  • cerebellum: 20 nTPM
  • basal ganglia: 20 nTPM
  • pons: 19 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about INTS13.

Disease | ImmuneIEDB

Conditions an epitope on INTS13 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.35
gnomAD pLI
0.86
DepMap mean gene effect
-0.41
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Cell cycle regulator Mat89Bb
  • Cell cycle and development regulator Mat89Bb

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of INTS13 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads INTS13 as an antibody target. Whether an autoantibody or antibody against INTS13 could matter depends on whether native INTS13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

INTS13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label INTS13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/INTS13. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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