Seroatlas · Human Serome Atlas

INTS10

Integrator complex subunit 10

Also known as: C8orf35, FLJ10569, INT10, INT10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NVR2
Gene: INTS10
Ensembl: ENSG00000104613
Chromosome: 8
Canonical length: 710 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

INTS10 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

710 residues, UniProt reviewed canonical sequence.

>Q9NVR2|INTS10
     1  MSAQGDCEFL VQRARELVPQ DLWAAKAWLI TARSLYPADF NIQYEMYTIE RNAERTATAG
    61  RLLYDMFVNF PDQPVVWREI SIITSALRND SQDKQTQFLR SLFETLPGRV QCEMLLKVTE
   121  QCFNTLERSE MLLLLLRRFP ETVVQHGVGL GEALLEAETI EEQESPVNCF RKLFVCDVLP
   181  LIINNHDVRL PANLLYKYLN KAAEFYINYV TRSTQIENQH QGAQDTSDLM SPSKRSSQKY
   241  IIEGLTEKSS QIVDPWERLF KILNVVGMRC EWQMDKGRRS YGDILHRMKD LCRYMNNFDS
   301  EAHAKYKNQV VYSTMLVFFK NAFQYVNSIQ PSLFQGPNAP SQVPLVLLED VSNVYGDVEI
   361  DRNKHIHKKR KLAEGREKTM SSDDEDCSAK GRNRHIVVNK AELANSTEVL ESFKLARESW
   421  ELLYSLEFLD KEFTRICLAW KTDTWLWLRI FLTDMIIYQG QYKKAIASLH HLAALQGSIS
   481  QPQITGQGTL EHQRALIQLA TCHFALGEYR MTCEKVLDLM CYMVLPIQDG GKSQEEPSKV
   541  KPKFRKGSDL KLLPCTSKAI MPYCLHLMLA CFKLRAFTDN RDDMALGHVI VLLQQEWPRG
   601  ENLFLKAVNK ICQQGNFQYE NFFNYVTNID MLEEFAYLRT QEGGKIHLEL LPNQGMLIKH
   661  HTVTRGITKG VKEDFRLAME RQVSRCGENL MVVLHRFCIN EKILLLQTLT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against INTS10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 50 nTPM

Expression across tissuesHPA

Tissue

pancreas: 50 nTPM
cerebellum: 45 nTPM
liver: 45 nTPM
thyroid gland: 41 nTPM
hippocampal formation: 37 nTPM
fallopian tube: 37 nTPM

Single-cell type

fallopian tube ciliated cells: 154 nCPM
adipocytes: 153 nCPM
adrenal medulla cells: 149 nCPM
endometrial ciliated cells: 143 nCPM
respiratory ciliated cells: 141 nCPM
rod photoreceptor cells: 135 nCPM

Immune cell

T-reg: 32 nTPM
myeloid DC: 31 nTPM
MAIT T-cell: 31 nTPM
naive CD4 T-cell: 28 nTPM
NK-cell: 28 nTPM
plasmacytoid DC: 27 nTPM

Brain region

white matter: 33 nTPM
cerebral cortex: 32 nTPM
cerebellum: 32 nTPM
basal ganglia: 31 nTPM
hypothalamus: 30 nTPM
medulla oblongata: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.16
gnomAD pLI: 1
gnomAD missense Z: 1.44
DepMap mean gene effect: -0.45
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Integrator complex subunit 10
Integrator subunit 10

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of INTS10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads INTS10 as an antibody target. Whether an autoantibody or antibody against INTS10 could matter depends on whether native INTS10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

INTS10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label INTS10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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