FSTL3
Follistatin-related protein 3
Also known as: FLRG, FSRP, FSTL3_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O95633
- Gene
- FSTL3
- Ensembl
- ENSG00000070404
- Chromosome
- 19
- Canonical length
- 263 aa
- Protein class
- Cancer-related genes, Disease related genes, Predicted intracellular proteins, Predicted secreted proteins
- Subcellular location
- Nucleoplasm
- Secretome location
- Secreted in other tissues
OverviewNCBI Gene
Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
263 residues, UniProt reviewed canonical sequence.
>O95633|FSTL3
1 MRPGAPGPLW PLPWGALAWA VGFVSSMGSG NPAPGGVCWL QQGQEATCSL VLQTDVTRAE
61 CCASGNIDTA WSNLTHPGNK INLLGFLGLV HCLPCKDSCD GVECGPGKAC RMLGGRPRCE
121 CAPDCSGLPA RLQVCGSDGA TYRDECELRA ARCRGHPDLS VMYRGRCRKS CEHVVCPRPQ
181 SCVVDQTGSA HCVVCRAAPC PVPSSPGQEL CGNNNVTYIS SCHMRQATCF LGRSIGVRHA
241 GSCAGTPEEP PGGESAEEEE NFVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against FSTL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.42
- Highest tissue expression
- 169 nTPM
Expression across tissuesHPA
Tissue
- placenta: 169 nTPM
- adrenal gland: 157 nTPM
- blood vessel: 151 nTPM
- lung: 129 nTPM
- heart muscle: 121 nTPM
- colon: 81 nTPM
Single-cell type
- extravillous trophoblasts: 5,795 nCPM
- syncytiotrophoblasts: 927 nCPM
- migrating cytotrophoblasts: 390 nCPM
- alveolar cells type 1: 378 nCPM
- hepatic stellate cells: 155 nCPM
- schwann cells: 142 nCPM
Immune cell
- classical monocyte: 1.9 nTPM
- intermediate monocyte: 1.8 nTPM
- non-classical monocyte: 1.4 nTPM
- naive CD4 T-cell: 1 nTPM
- myeloid DC: 0.9 nTPM
- total PBMC: 0.9 nTPM
Brain region
- medulla oblongata: 41 nTPM
- thalamus: 32 nTPM
- white matter: 32 nTPM
- cerebral cortex: 31 nTPM
- pons: 31 nTPM
- hypothalamus: 30 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.59
- gnomAD pLI
- 0.69
- gnomAD missense Z
- 1.57
- DepMap mean gene effect
- -0.01
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- cell differentiation
- hematopoietic progenitor cell differentiation
- negative regulation of activin receptor signaling pathway
- negative regulation of BMP signaling pathway
- negative regulation of osteoclast differentiation
- ossification
- positive regulation of cell-cell adhesion
- positive regulation of transcription by RNA polymerase II
- regulation of BMP signaling pathway
- regulation of transcription by RNA polymerase II
- negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Kazal domain
- Follistatin-like, N-terminal
- Follistatin/Osteonectin EGF domain
- TB domain
- Kazal domain superfamily
- TGF-beta binding (TB) domain superfamily
- Protease Inhibitors and Growth Factor Antagonists
- Kazal-type serine protease inhibitor domain
- Follistatin/Osteonectin-like EGF domain
- Follistatin, N-terminal
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of FSTL3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads FSTL3 as an antibody target. Whether an autoantibody or antibody against FSTL3 could matter depends on whether native FSTL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
FSTL3 is annotated as secreted, so native FSTL3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label FSTL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...