ACVR2A

Protein identityUniProt · HPA

UniProt accession

P27037

Gene

ACVR2A

Ensembl

ENSG00000121989

Chromosome

2

Canonical length

513 aa

Protein class

Cancer-related genes, Enzymes, Predicted membrane proteins

Subcellular location

Cytosol

OverviewNCBI Gene

This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013]

Canonical amino-acid sequenceUniProt

513 residues, UniProt reviewed canonical sequence.

>P27037|ACVR2A
     1  MGAAAKLAFA VFLISCSSGA ILGRSETQEC LFFNANWEKD RTNQTGVEPC YGDKDKRRHC
    61  FATWKNISGS IEIVKQGCWL DDINCYDRTD CVEKKDSPEV YFCCCEGNMC NEKFSYFPEM
   121  EVTQPTSNPV TPKPPYYNIL LYSLVPLMLI AGIVICAFWV YRHHKMAYPP VLVPTQDPGP
   181  PPPSPLLGLK PLQLLEVKAR GRFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEVYSLPG
   241  MKHENILQFI GAEKRGTSVD VDLWLITAFH EKGSLSDFLK ANVVSWNELC HIAETMARGL
   301  AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG KSAGDTHGQV
   361  GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR CTAADGPVDE YMLPFEEEIG
   421  QHPSLEDMQE VVVHKKKRPV LRDYWQKHAG MAMLCETIEE CWDHDAEARL SAGCVGERIT
   481  QMQRLTNIIT TEDIVTVVTM VTNVDFPPKE SSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACVR2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.34

Highest tissue expression

18 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.17

gnomAD pLI

1

gnomAD missense Z

3.29

DepMap mean gene effect

-0.04

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• activin receptor signaling pathway
• anterior/posterior pattern specification
• BMP signaling pathway
• cell surface receptor protein serine/threonine kinase signaling pathway
• cellular response to BMP stimulus
• cellular response to growth factor stimulus
• determination of left/right symmetry
• embryonic skeletal system development
• gastrulation with mouth forming second
• mesoderm development
• odontogenesis of dentin-containing tooth
• osteoblast differentiation
• pattern specification process
• penile erection
• positive regulation of activin receptor signaling pathway
• positive regulation of bone mineralization
• positive regulation of erythrocyte differentiation
• positive regulation of osteoblast differentiation
• positive regulation of protein phosphorylation
• positive regulation of SMAD protein signal transduction
• positive regulation of transcription by RNA polymerase II
• regulation of nitric oxide biosynthetic process
• Sertoli cell proliferation
• sperm ejaculation
• spermatogenesis

Molecular functions

• activin binding
• activin receptor activity
• activin receptor activity, type I
• activin receptor activity, type II
• ATP binding
• BMP receptor activity
• coreceptor activity
• growth factor binding
• identical protein binding
• inhibin binding
• metal ion binding
• PDZ domain binding
• protein serine/threonine kinase activity
• transmembrane receptor protein serine/threonine kinase activity

Cellular components

• activin receptor complex
• cell surface
• cytoplasm
• inhibin-betaglycan-ActRII complex
• plasma membrane
• receptor complex

Protein domainsUniProt · Pfam · InterPro

• Ser/Thr protein kinase, TGFB receptor
• Activin types I and II receptor domain
• Protein kinase domain
• Serine/threonine-protein kinase, active site
• Protein kinase-like domain superfamily
• Snake toxin-like superfamily
• Protein kinase domain
• Activin types I and II receptor domain

KeywordsUniProt

• ATP-binding
• Cell membrane
• Disulfide bond
• Glycoprotein
• Kinase
• Magnesium
• Manganese
• Membrane
• Metal-binding
• Nucleotide-binding
• Receptor
• Serine/threonine-protein kinase
• Signal
• Transferase
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of ACVR2A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• BMP7
• MAGI2
• INHBA
• ACVR1
• GDF11
• IGSF1