Seroatlas · Human Serome Atlas

JADE2

E3 ubiquitin-protein ligase Jade-2

Also known as: JADE-2, JADE2_HUMAN, KIAA0239, PHF15

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NQC1
Gene: JADE2
Ensembl: ENSG00000043143
Chromosome: 5
Canonical length: 790 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables histone H4K12 acetyltransferase activity; histone H4K5 acetyltransferase activity; and histone H4K8 acetyltransferase activity. Contributes to histone H3K14 acetyltransferase activity. Involved in regulation of DNA biosynthetic process; regulation of DNA replication; and regulation of cell cycle. Located in nucleoplasm. Part of histone acetyltransferase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

790 residues, UniProt reviewed canonical sequence.

>Q9NQC1|JADE2
     1  MEEKRRKYSI SSDNSDTTDS HATSTSASRC SKLPSSTKSG WPRQNEKKPS EVFRTDLITA
    61  MKIPDSYQLS PDDYYILADP WRQEWEKGVQ VPAGAEAIPE PVVRILPPLE GPPAQASPSS
   121  TMLGEGSQPD WPGGSRYDLD EIDAYWLELI NSELKEMERP ELDELTLERV LEELETLCHQ
   181  NMARAIETQE GLGIEYDEDV VCDVCRSPEG EDGNEMVFCD KCNVCVHQAC YGILKVPTGS
   241  WLCRTCALGV QPKCLLCPKR GGALKPTRSG TKWVHVSCAL WIPEVSIGCP EKMEPITKIS
   301  HIPASRWALS CSLCKECTGT CIQCSMPSCV TAFHVTCAFD HGLEMRTILA DNDEVKFKSF
   361  CQEHSDGGPR NEPTSEPTEP SQAGEDLEKV TLRKQRLQQL EEDFYELVEP AEVAERLDLA
   421  EALVDFIYQY WKLKRKANAN QPLLTPKTDE VDNLAQQEQD VLYRRLKLFT HLRQDLERVR
   481  NLCYMVTRRE RTKHAICKLQ EQIFHLQMKL IEQDLCRGLS TSFPIDGTFF NSWLAQSVQI
   541  TAENMAMSEW PLNNGHREDP APGLLSEELL QDEETLLSFM RDPSLRPGDP ARKARGRTRL
   601  PAKKKPPPPP PQDGPGSRTT PDKAPKKTWG QDAGSGKGGQ GPPTRKPPRR TSSHLPSSPA
   661  AGDCPILATP ESPPPLAPET PDEAASVAAD SDVQVPGPAA SPKPLGRLRP PRESKVTRRL
   721  PGARPDAGMG PPSAVAERPK VSLHFDTETD GYFSDGEMSD SDVEAEDGGV QRGPREAGAE
   781  EVVRMGVLAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against JADE2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

lymph node: 22 nTPM
parathyroid gland: 19 nTPM
spleen: 19 nTPM
adrenal gland: 16 nTPM
ovary: 16 nTPM
cerebellum: 16 nTPM

Single-cell type

adrenal medulla cells: 64 nCPM
b-cells: 58 nCPM
proximal tubule cells: 56 nCPM
thyrotrophs: 56 nCPM
kupffer cells: 55 nCPM
t-cells: 51 nCPM

Immune cell

memory B-cell: 3.6 nTPM
MAIT T-cell: 3.3 nTPM
gdT-cell: 3.1 nTPM
T-reg: 3.1 nTPM
memory CD4 T-cell: 3 nTPM
memory CD8 T-cell: 3 nTPM

Brain region

cerebral cortex: 46 nTPM
white matter: 45 nTPM
hypothalamus: 45 nTPM
medulla oblongata: 44 nTPM
basal ganglia: 42 nTPM
pons: 42 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.17
gnomAD pLI: 1
gnomAD missense Z: 2.46
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of JADE2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads JADE2 as an antibody target. Whether an autoantibody or antibody against JADE2 could matter depends on whether native JADE2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

JADE2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label JADE2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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