Seroatlas · Human Serome Atlas

TMEM11

Transmembrane protein 11, mitochondrial

Also known as: C17orf35, PM1, PMI, TMM11_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P17152
Gene: TMEM11
Ensembl: ENSG00000178307
Chromosome: 17
Canonical length: 192 aa
Protein class: Predicted membrane proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Involved in mitochondrion organization. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

192 residues, UniProt reviewed canonical sequence.

>P17152|TMEM11
     1  MAAWGRRRLG PGSSGGSARE RVSLSATDCY IVHEIYNGEN AQDQFEYELE QALEAQYKYI
    61  VIEPTRIGDE TARWITVGNC LHKTAVLAGT ACLFTPLALP LDYSHYISLP AGVLSLACCT
   121  LYGISWQFDP CCKYQVEYDA YKLSRLPLHT LTSSTPVVLV RKDDLHRKRL HNTIALAALV
   181  YCVKKIYELY AV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 76 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 76 nTPM
tongue: 51 nTPM
bone marrow: 36 nTPM
heart muscle: 30 nTPM
skin: 29 nTPM
pancreas: 29 nTPM

Single-cell type

esophageal apical cells: 161 nCPM
esophageal suprabasal cells: 110 nCPM
migrating cytotrophoblasts: 103 nCPM
syncytiotrophoblasts: 102 nCPM
esophageal basal cells: 97 nCPM
extravillous trophoblasts: 92 nCPM

Immune cell

eosinophil: 76 nTPM
classical monocyte: 71 nTPM
non-classical monocyte: 68 nTPM
total PBMC: 68 nTPM
intermediate monocyte: 59 nTPM
neutrophil: 59 nTPM

Brain region

cerebellum: 18 nTPM
medulla oblongata: 17 nTPM
hypothalamus: 16 nTPM
cerebral cortex: 15 nTPM
thalamus: 15 nTPM
pons: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.43
gnomAD pLI: 0.88
gnomAD missense Z: 1.35
DepMap mean gene effect: -0.25
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Transmembrane protein 11
Mitochondrial morphogenesis regulator

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM11 as an antibody target. Whether an autoantibody or antibody against TMEM11 could matter depends on whether native TMEM11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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