Seroatlas · Human Serome Atlas

EDRF1

Erythroid differentiation-related factor 1

Also known as: C10orf137, DKFZp586F1019, EDRF1_HUMAN, FLJ21617

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q3B7T1
Gene: EDRF1
Ensembl: ENSG00000107938
Chromosome: 10
Canonical length: 1238 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Centrosome,Cytosol

OverviewNCBI Gene

This gene may play a role in erythroid cell differentiation. The encoded protein inhibits DNA binding of the erythroid transcription factor GATA-1 and may regulate the expression of alpha-globin and gamma-globin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Canonical amino-acid sequenceUniProt

1238 residues, UniProt reviewed canonical sequence.

>Q3B7T1|EDRF1
     1  MGDAKEAGAE GPPAGAAARG GLSLLSQGES EESSAQGSAL FLGGNEVKSR AVVKYSSAPP
    61  RTAFARLEEK TDLKLPPANW LRESAKLGPA GTTILGNSKK SKPFSSFGMA YDFIDSVGND
   121  VDVVSDSENI KKLLKIPYSK SHVSMAVHRI GRTLLLDELD IQELFMRSSQ TGDWTWLKEF
   181  YQRLIDQKWQ RKKKSKEHWY QKAILSKFLY YSINGDGAAQ PVSSTAEQQE SSSSDQTNDS
   241  EGASWPAPFE MPSSVSEDPS ASSQGSEPLE PSYIVGHVAS APKEQNLITL FNDGEHSQGL
   301  KNDFVRNILW TFEDIHMLVG SNMPIFGGGR YPAVSLRLRD NNKPINVLTG IDYWLDNLIC
   361  NVPELVMCFH VNGIVQKYEM IKTEEIPNLE NSNFSTKVIK DIAQNILSFL KSNCTKEGHT
   421  YWLFKASGSD IVKLYDLTTL CEETEDKYQN PFTMPVAILL YKVACNMMMK KNQNKKHYGT
   481  IRTLLLNCLK LLDKSRHPQI IASANYMLSE LFQLDEPKKE ENSESPLNEN SDESYSEEEE
   541  EMPDSDENGS YSTSSDPSDD SKAVAIIKSV GELSVPEKYK SIHQIRPSCA FPVCHDTEER
   601  CRLVLSYVLE GLKSVDSSIK KESDLPAADP STPIPLKYED ESSRGGPEGL EKQMALFLDK
   661  MGSLQKGNYS SQSGMIPGSW QHKMKLQLIL KSSKAYYVLS DAAMSLQKYG RALRYIKLAL
   721  QSHDTYCCLC TNMLSEVLLF LSQYLTLCGD IQLMLAQNAN NRAAHLEEFH YQTKEDQEIL
   781  HSLHRESSCQ GFAWATDLST DLESQLSVSC KCYEAANEIL QFSDLKSQNP EHYVQVLKRM
   841  GNIRNEIGVF YMNQAAALQS ERLVSKSVSA AEQQLWKKSF SCFEKGIHNF ESIEDATNAA
   901  LLLCNTGRLM RICAQAHCGA GDELKREFSP EEGLYYNKAI DYYLKALRSL GTRDIHPAVW
   961  DSVNWELSTT YFTMATLQQD YAPLSRKAQE QIEKEVSEAM MKSLKYCDVD SVSARQPLCQ
  1021  YRAATIHHRL ASMYHSCLRN QVGDEHLRKQ HRVLADLHYS KAAKLFQLLK DAPCELLRVQ
  1081  LERVAFAEFQ MTSQNSNVGK LKTLSGALDI MVRTEHAFQL IQKELIEEFG QPKSGDAAAA
  1141  ADASPSLNRE EVMKLLSIFE SRLSFLLLQS IKLLSSTKKK TSNNIEDDTI LKTNKHIYSQ
  1201  LLRATANKTA TLLERINVIV HLLGQLAAGS AASSNAVQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EDRF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 20 nTPM
testis: 14 nTPM
salivary gland: 12 nTPM
lymph node: 9 nTPM
thymus: 8.8 nTPM
tonsil: 7.8 nTPM

Single-cell type

early spermatids: 257 nCPM
sertoli cells: 175 nCPM
endometrial glandular cells: 89 nCPM
somatotrophs: 79 nCPM
late spermatids: 79 nCPM
lactotrophs: 77 nCPM

Immune cell

basophil: 5.5 nTPM
MAIT T-cell: 3.4 nTPM
T-reg: 3.1 nTPM
memory B-cell: 3 nTPM
myeloid DC: 3 nTPM
naive CD8 T-cell: 2.9 nTPM

Brain region

cerebellum: 18 nTPM
white matter: 15 nTPM
hippocampal formation: 14 nTPM
cerebral cortex: 13 nTPM
choroid plexus: 13 nTPM
basal ganglia: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.4
gnomAD pLI: 0
gnomAD missense Z: 2.7
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

positive regulation of DNA-templated transcription

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

EDRF1, N-terminal
EDRF1, TPR repeats region
Erythroid differentiation-related factor 1-like, TPR repeats
EDRF1 N-terminal

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EDRF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

HSPBP1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EDRF1 as an antibody target. Whether an autoantibody or antibody against EDRF1 could matter depends on whether native EDRF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EDRF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EDRF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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