POLN

Protein identityUniProt · HPA

UniProt accession

Q7Z5Q5

Gene

POLN

Ensembl

ENSG00000130997

Chromosome

4

Canonical length

900 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm

OverviewNCBI Gene

This gene encodes a DNA polymerase type-A family member. The encoded protein plays a role in DNA repair and homologous recombination. This gene shares its 5' exons with some transcripts from overlapping GeneID: 79441, which encodes an augmentin-like protein complex subunit. [provided by RefSeq, Dec 2014]

Canonical amino-acid sequenceUniProt

900 residues, UniProt reviewed canonical sequence.

>Q7Z5Q5|POLN
     1  MENYEALVGF DLCNTPLSSV AQKIMSAMHS GDLVDSKTWG KSTETMEVIN KSSVKYSVQL
    61  EDRKTQSPEK KDLKSLRSQT SRGSAKLSPQ SFSVRLTDQL SADQKQKSIS SLTLSSCLIP
   121  QYNQEASVLQ KKGHKRKHFL MENINNENKG SINLKRKHIT YNNLSEKTSK QMALEEDTDD
   181  AEGYLNSGNS GALKKHFCDI RHLDDWAKSQ LIEMLKQAAA LVITVMYTDG STQLGADQTP
   241  VSSVRGIVVL VKRQAEGGHG CPDAPACGPV LEGFVSDDPC IYIQIEHSAI WDQEQEAHQQ
   301  FARNVLFQTM KCKCPVICFN AKDFVRIVLQ FFGNDGSWKH VADFIGLDPR IAAWLIDPSD
   361  ATPSFEDLVE KYCEKSITVK VNSTYGNSSR NIVNQNVREN LKTLYRLTMD LCSKLKDYGL
   421  WQLFRTLELP LIPILAVMES HAIQVNKEEM EKTSALLGAR LKELEQEAHF VAGERFLITS
   481  NNQLREILFG KLKLHLLSQR NSLPRTGLQK YPSTSEAVLN ALRDLHPLPK IILEYRQVHK
   541  IKSTFVDGLL ACMKKGSISS TWNQTGTVTG RLSAKHPNIQ GISKHPIQIT TPKNFKGKED
   601  KILTISPRAM FVSSKGHTFL AADFSQIELR ILTHLSGDPE LLKLFQESER DDVFSTLTSQ
   661  WKDVPVEQVT HADREQTKKV VYAVVYGAGK ERLAACLGVP IQEAAQFLES FLQKYKKIKD
   721  FARAAIAQCH QTGCVVSIMG RRRPLPRIHA HDQQLRAQAE RQAVNFVVQG SAADLCKLAM
   781  IHVFTAVAAS HTLTARLVAQ IHDELLFEVE DPQIPECAAL VRRTMESLEQ VQALELQLQV
   841  PLKVSLSAGR SWGHLVPLQE AWGPPPGPCR TESPSNSLAA PGSPASTQPP PLHFSPSFCL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against POLN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.36

Highest tissue expression

2.2 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.42

gnomAD pLI

0

gnomAD missense Z

-0.05

DepMap mean gene effect

0

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• DNA synthesis involved in DNA repair
• DNA-templated DNA replication
• double-strand break repair
• double-strand break repair via homologous recombination
• interstrand cross-link repair
• translesion synthesis

Molecular functions

• cyclin binding
• DNA binding
• DNA-directed DNA polymerase activity

Cellular components

• nucleoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• DNA-directed DNA polymerase, family A, palm domain
• DNA polymerase A
• Ribonuclease H superfamily
• DNA/RNA polymerase superfamily
• DNA polymerase family A
• DNA polymerase nu, pseudo-exo domain
• DNA polymerase nu pseudo-exo

KeywordsUniProt

• DNA damage
• DNA repair
• DNA replication
• DNA-binding
• DNA-directed DNA polymerase
• Nucleotidyltransferase
• Nucleus
• Transferase

InteractionsUniProt · HPA

Protein binding partners of POLN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• FANCD2
• FANCI
• HELQ
• PCNA
• RAD51
• TRAIP