MAP3K7CL
MAP3K7 C-terminal-like protein
Also known as: C21orf7, M3KCL_HUMAN, TAK1L, TAKL, TAKL-1, TAKL-2, TAKL-4
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P57077
- Gene
- MAP3K7CL
- Ensembl
- ENSG00000156265
- Chromosome
- 21
- Canonical length
- 142 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
142 residues, UniProt reviewed canonical sequence.
>P57077|MAP3K7CL
1 MISTARVPAD KPVRIAFSLN DASDDTPPED SIPLVFPELD QQLQPLPPCH DSEESMEVFK
61 QHCQIAEEYH EVKKEITLLE QRKKELIAKL DQAEKEKVDA AELVREFEAL TEENRTLRLA
121 QSQCVEQLEK LRIQYQKRQG SSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MAP3K7CL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.52
- Highest tissue expression
- 43 nTPM
Expression across tissuesHPA
Tissue
- tongue: 43 nTPM
- skeletal muscle: 37 nTPM
- blood vessel: 31 nTPM
- heart muscle: 27 nTPM
- lung: 9.4 nTPM
- lymph node: 8.9 nTPM
Single-cell type
- platelets: 740 nCPM
- sertoli cells: 120 nCPM
- thymic myoid cells: 90 nCPM
- vascular smooth muscle cells: 86 nCPM
- thyrotrophs: 73 nCPM
- adrenal cortex cells: 69 nCPM
Immune cell
- total PBMC: 96 nTPM
- basophil: 53 nTPM
- naive B-cell: 23 nTPM
- neutrophil: 21 nTPM
- memory B-cell: 18 nTPM
- classical monocyte: 14 nTPM
Brain region
- medulla oblongata: 19 nTPM
- hypothalamus: 18 nTPM
- midbrain: 17 nTPM
- amygdala: 17 nTPM
- white matter: 17 nTPM
- cerebral cortex: 16 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.6
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.63
- DepMap mean gene effect
- 0
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
- MAP3K7 C-terminal-like protein
InteractionsUniProt · HPA
Protein binding partners of MAP3K7CL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MAP3K7CL as an antibody target. Whether an autoantibody or antibody against MAP3K7CL could matter depends on whether native MAP3K7CL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MAP3K7CL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label MAP3K7CL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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