Seroatlas · Human Serome Atlas

BUD13

BUD13 homolog

Also known as: BUD13_HUMAN, Cwc26, fSAP71, MGC13125

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BRD0
Gene: BUD13
Ensembl: ENSG00000137656
Chromosome: 11
Canonical length: 619 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in nucleoplasm. Part of U2-type precatalytic spliceosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

619 residues, UniProt reviewed canonical sequence.

>Q9BRD0|BUD13
     1  MAAAPPLSKA EYLKRYLSGA DAGVDRGSES GRKRRKKRPK PGGAGGKGMR IVDDDVSWTA
    61  ISTTKLEKEE EEDDGDLPVV AEFVDERPEE VKQMEAFRSS AKWKLLGGHN EDLPSNRHFR
   121  HDTPDSSPRR VRHGTPDPSP RKDRHDTPDP SPRRARHDTP DPSPLRGARH DSDTSPPRRI
   181  RHDSSDTSPP RRARHDSPDP SPPRRPQHNS SGASPRRVRH DSPDPSPPRR ARHGSSDISS
   241  PRRVHNNSPD TSRRTLGSSD TQQLRRARHD SPDLAPNVTY SLPRTKSGKA PERASSKTSP
   301  HWKESGASHL SFPKNSKYEY DPDISPPRKK QAKSHFGDKK QLDSKGDCQK ATDSDLSSPR
   361  HKQSPGHQDS DSDLSPPRNR PRHRSSDSDL SPPRRRQRTK SSDSDLSPPR RSQPPGKKAA
   421  HMYSGAKTGL VLTDIQREQQ ELKEQDQETM AFEAEFQYAE TVFRDKSGRK RNLKLERLEQ
   481  RRKAEKDSER DELYAQWGKG LAQSRQQQQN VEDAMKEMQK PLARYIDDED LDRMLREQER
   541  EGDPMANFIK KNKAKENKNK KVRPRYSGPA PPPNRFNIWP GYRWDGVDRS NGFEQKRFAR
   601  LASKKAVEEL AYKWSVEDM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BUD13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

thymus: 24 nTPM
testis: 20 nTPM
tonsil: 18 nTPM
ovary: 16 nTPM
lymph node: 15 nTPM
endometrium: 14 nTPM

Single-cell type

late primary spermatocytes: 62 nCPM
early primary spermatocytes: 42 nCPM
differentiating spermatogonia: 27 nCPM
enterocytes: 25 nCPM
monocyte progenitors: 25 nCPM
medullary thymic epithelial cells: 24 nCPM

Immune cell

eosinophil: 20 nTPM
basophil: 16 nTPM
MAIT T-cell: 11 nTPM
memory B-cell: 11 nTPM
gdT-cell: 10 nTPM
naive CD4 T-cell: 9.6 nTPM

Brain region

cerebellum: 17 nTPM
white matter: 16 nTPM
pons: 13 nTPM
basal ganglia: 13 nTPM
cerebral cortex: 13 nTPM
hypothalamus: 13 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about BUD13.

Disease | AllUniProt

Conditions BUD13 is implicated in, by any mechanism.

Achalasia-progeroid syndrome (ACHPS) MIM:621123

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 135 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Achalasia-progeroid syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.77
gnomAD pLI: 0
gnomAD missense Z: -0.21
DepMap mean gene effect: -0.78
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Bud13
Pre-mRNA-splicing factor CWC26
Pre-mRNA-splicing factor of RES complex

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BUD13 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BUD13 as an antibody target. Whether an autoantibody or antibody against BUD13 could matter depends on whether native BUD13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BUD13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BUD13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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