PRKACB

Protein identityUniProt · HPA

UniProt accession

P22694

Gene

PRKACB

Ensembl

ENSG00000142875

Chromosome

1

Canonical length

351 aa

Protein class

Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins

Subcellular location

Microtubules,Cytokinetic bridge,Primary cilium,Basal body,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the serine/threonine protein kinase family. The encoded protein is a catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase, which mediates signalling though cAMP. cAMP signaling is important to a number of processes, including cell proliferaton and differentiation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

351 residues, UniProt reviewed canonical sequence.

>P22694|PRKACB
     1  MGNAATAKKG SEVESVKEFL AKAKEDFLKK WENPTQNNAG LEDFERKKTL GTGSFGRVML
    61  VKHKATEQYY AMKILDKQKV VKLKQIEHTL NEKRILQAVN FPFLVRLEYA FKDNSNLYMV
   121  MEYVPGGEMF SHLRRIGRFS EPHARFYAAQ IVLTFEYLHS LDLIYRDLKP ENLLIDHQGY
   181  IQVTDFGFAK RVKGRTWTLC GTPEYLAPEI ILSKGYNKAV DWWALGVLIY EMAAGYPPFF
   241  ADQPIQIYEK IVSGKVRFPS HFSSDLKDLL RNLLQVDLTK RFGNLKNGVS DIKTHKWFAT
   301  TDWIAIYQRK VEAPFIPKFR GSGDTSNFDD YEEEDIRVSI TEKCAKEFGE F

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRKACB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.25

Highest tissue expression

179 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PRKACB.

Disease | AllUniProt

Conditions PRKACB is implicated in, by any mechanism.

• Cardioacrofacial dysplasia 2 (CAFD2) MIM:619143

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 75 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Cardioacrofacial dysplasia 2

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.48

gnomAD pLI

0.35

gnomAD missense Z

2.8

DepMap mean gene effect

-0.04

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• adenylate cyclase-activating G protein-coupled receptor signaling pathway
• adenylate cyclase-modulating G protein-coupled receptor signaling pathway
• dorsal/ventral neural tube patterning
• high-density lipoprotein particle assembly
• negative regulation of smoothened signaling pathway
• negative regulation of TORC1 signaling
• neural tube closure
• positive regulation of insulin secretion
• protein phosphorylation
• regulation of protein processing
• renal water homeostasis
• signal transduction
• vascular endothelial cell response to laminar fluid shear stress

Molecular functions

• ATP binding
• cAMP-dependent protein kinase activity
• magnesium ion binding
• potassium channel inhibitor activity
• protein serine kinase activity
• protein serine/threonine kinase activity
• ubiquitin protein ligase binding

Cellular components

• cAMP-dependent protein kinase complex
• centrosome
• ciliary base
• cytosol
• extracellular exosome
• nucleoplasm
• nucleus
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Protein kinase domain
• AGC-kinase, C-terminal
• Serine/threonine-protein kinase, active site
• Protein kinase-like domain superfamily
• Protein kinase, ATP binding site
• cAMP-dependent protein kinase catalytic subunit
• Protein kinase domain

KeywordsUniProt

• ATP-binding
• cAMP
• Cell membrane
• Cytoplasm
• Kinase
• Lipoprotein
• Membrane
• Myristate
• Nucleotide-binding
• Nucleus
• Phosphoprotein
• Serine/threonine-protein kinase
• Transferase

InteractionsUniProt · HPA

Protein binding partners of PRKACB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• GPKOW
• PRKAR1A
• PRKAR2B
• HSP90AB1