Seroatlas · Human Serome Atlas

PPM1F

Protein phosphatase 1F

Also known as: CAMKP, CaMKPase, FEM-2, KIAA0015, POPX2, PPM1F_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P49593
Gene
PPM1F
Ensembl
ENSG00000100034
Chromosome
22
Canonical length
454 aa
Protein class
Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Plasma membrane

OverviewNCBI Gene

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

454 residues, UniProt reviewed canonical sequence.

>P49593|PPM1F
     1  MSSGAPQKSS PMASGAEETP GFLDTLLQDF PALLNPEDPL PWKAPGTVLS QEEVEGELAE
    61  LAMGFLGSRK APPPLAAALA HEAVSQLLQT DLSEFRKLPR EEEEEEEDDD EEEKAPVTLL
   121  DAQSLAQSFF NRLWEVAGQW QKQVPLAARA SQRQWLVSIH AIRNTRRKME DRHVSLPSFN
   181  QLFGLSDPVN RAYFAVFDGH GGVDAARYAA VHVHTNAARQ PELPTDPEGA LREAFRRTDQ
   241  MFLRKAKRER LQSGTTGVCA LIAGATLHVA WLGDSQVILV QQGQVVKLME PHRPERQDEK
   301  ARIEALGGFV SHMDCWRVNG TLAVSRAIGD VFQKPYVSGE ADAASRALTG SEDYLLLACD
   361  GFFDVVPHQE VVGLVQSHLT RQQGSGLRVA EELVAAARER GSHDNITVMV VFLRDPQELL
   421  EGGNQGEGDP QAEGRRQDLP SSLPEPETQA PPRS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPM1F can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
34 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 34 nTPM
  • bone marrow: 25 nTPM
  • placenta: 25 nTPM
  • lung: 25 nTPM
  • adipose tissue: 23 nTPM
  • esophagus: 21 nTPM

Single-cell type

  • neutrophils: 221 nCPM
  • monocytes: 81 nCPM
  • lymphatic endothelial cells: 77 nCPM
  • vascular endothelial cells: 66 nCPM
  • megakaryocytes: 56 nCPM
  • megakaryocyte progenitors: 54 nCPM

Immune cell

  • neutrophil: 29 nTPM
  • non-classical monocyte: 25 nTPM
  • intermediate monocyte: 21 nTPM
  • classical monocyte: 13 nTPM
  • myeloid DC: 9 nTPM
  • eosinophil: 5.9 nTPM

Brain region

  • hypothalamus: 47 nTPM
  • pons: 44 nTPM
  • medulla oblongata: 42 nTPM
  • midbrain: 42 nTPM
  • spinal cord: 39 nTPM
  • white matter: 38 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.75
gnomAD pLI
0
gnomAD missense Z
1.31
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPM1F in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPM1F as an antibody target. Whether an autoantibody or antibody against PPM1F could matter depends on whether native PPM1F is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPM1F is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPM1F as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PPM1F. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...