Seroatlas · Human Serome Atlas

PHTF1

Protein PHTF1

Also known as: PHTF, PHTF1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UMS5
Gene: PHTF1
Ensembl: ENSG00000116793
Chromosome: 1
Canonical length: 762 aa
Protein class: Plasma proteins, Predicted membrane proteins, Transcription factors
Subcellular location: Nucleoli,Nuclear bodies

OverviewNCBI Gene

Predicted to be located in cis-Golgi network membrane and endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

762 residues, UniProt reviewed canonical sequence.

>Q9UMS5|PHTF1
     1  MASNERDAIS WYQKKIGAYD QQIWEKSIEQ TQIKGLKNKP KKMGHIKPDL IDVDLIRGST
    61  FAKAKPEIPW TSLTRKGLVR VVFFPLFSNW WIQVTSLRIF VWLLLLYFMQ VIAIVLYLMM
   121  PIVNISEVLG PLCLMLLMGT VHCQIVSTQI TRPSGNNGNR RRRKLRKTVN GDGSRENGNN
   181  SSDKVRGIET LESVPIIGGF WETIFGNRIK RVKLISNKGT ETDNDPSCVH PIIKRRQCRP
   241  EIRMWQTREK AKFSDGEKCR REAFRRLGNG VSDDLSSEED GEARTQMILL RRSVEGASSD
   301  NGCEVKNRKS ILSRHLNSQV KKTTTRWCHI VRDSDSLAES EFESAAFSQG SRSGVSGGSR
   361  SLNMSRRDSE STRHDSETED MLWDDLLHGP ECRSSVTSDS EGAHVNTLHS GTKRDPKEDV
   421  FQQNHLFWLQ NSSPSSDRVS AIIWEGNECK KMDMSVLEIS GIIMSRVNAY QQGVGYQMLG
   481  NVVTIGLAFF PFLHRLFREK SLDQLKSISA EEILTLFCGA PPVTPIIVLS IINFFERLCL
   541  TWMFFFMMCV AERTYKQRFL FAKLFSHITS ARKARKYEIP HFRLKKVENI KIWLSLRSYL
   601  KRRGPQRSVD VVVSSVFLLT LSIAFICCAQ VLQGHKTFLN DAYNWEFLIW ETALLLFLLR
   661  LASLGSETNK KYSNVSILLT EQINLYLKME KKPNKKEQLT LVNNVLKLST KLLKELDTPF
   721  RLYGLTMNPL IYNITRVVIL SAVSGVISDL LGFNIRLWKI KS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PHTF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 8
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

testis: 28 nTPM
choroid plexus: 27 nTPM
bone marrow: 18 nTPM
cerebellum: 14 nTPM
retina: 13 nTPM
pituitary gland: 12 nTPM

Single-cell type

megakaryocyte-erythroid progenitors: 662 nCPM
neutrophils: 485 nCPM
late primary spermatocytes: 257 nCPM
megakaryocyte progenitors: 223 nCPM
innate lymphoid cells: 185 nCPM
early spermatids: 176 nCPM

Immune cell

T-reg: 3 nTPM
neutrophil: 2.9 nTPM
eosinophil: 2.5 nTPM
NK-cell: 2.2 nTPM
myeloid DC: 2.1 nTPM
memory B-cell: 1.7 nTPM

Brain region

choroid plexus: 38 nTPM
cerebellum: 30 nTPM
hypothalamus: 17 nTPM
pons: 17 nTPM
cerebral cortex: 15 nTPM
thalamus: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.17
gnomAD pLI: 0
gnomAD missense Z: 1.02
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PHTF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

FEM1B

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PHTF1 as an antibody target. Whether an autoantibody or antibody against PHTF1 could matter depends on whether native PHTF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PHTF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PHTF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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