JHDM1 Histone Demethylase
IPR050690
Definition
The JHDM1 histone demethylase family is involved in the regulation of gene expression through the specific demethylation of histone lysine residues, which is central to the histone code. Members of this family demethylate various lysine positions on histone H3, such as 'Lys-4', 'Lys-9', 'Lys-27', 'Lys-36', and on histone H4 'Lys-20', with preferences for certain methylation states. These demethylases play key roles in processes such as brain development, cell cycle progression, transcriptional regulation, and maintenance of heterochromatin stability. Some family members also have non-histone substrates, influencing other cellular pathways. The family includes proteins with domains such as JmjC, PHD-type zinc fingers, CXXC zinc fingers, and F-box domains, which contribute to their demethylase activity, substrate specificity, and additional cellular functions.
6 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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