CXXC zinc finger domain

Definition

This domain contains eight conserved cysteine residues that bind to two zinc ions. The CXXC domain is found in a variety of chromatin-associated proteins. This domain binds to nonmethyl-CpG dinucleotides. The domain is characterised by two repeats PMID:16990798, and shows a peculiar internal duplication in which the second unit is inserted into the first one PMID:21507349. Each of these units is characterised by four conserved cysteines, displaying a CXXCXXCX(n)C motif that chelate a Zn+2 ion. The DNA binding interface has been identified by NMR PMID:16990798. In eukaryotes, the CXXC domain is found in stramenopiles, plants and metazoans. Plants possess a mono-CXXC domain that is present in distinct chromatin proteins PMID:21507349. Structural comparisons show that the mono-CXXC is homologous to the structural-zinc binding domain of medium chain dehydrogenases PMID:21507349.

12 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (12 proteins: gene, accession, name)

• CXXC1
• CXXC4
• CXXC5
• DNMT1
• FBXL19
• KDM2A
• KDM2B
• KMT2A
• KMT2B
• MBD1
• TET1
• TET3