Seroatlas · Human Serome Atlas

ELL

RNA polymerase II elongation factor ELL

Also known as: C19orf17, ELL_HUMAN, ELL1, Men, PPP1R68

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P55199
Gene
ELL
Ensembl
ENSG00000105656
Chromosome
19
Canonical length
621 aa
Protein class
Cancer-related genes, Disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear bodies,Cytosol

OverviewNCBI Gene

Enables phosphatase binding activity. Involved in positive regulation of DNA-templated transcription and snRNA transcription. Located in cytosol; euchromatin; and nuclear body. Part of transcription elongation factor complex. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

621 residues, UniProt reviewed canonical sequence.

>P55199|ELL
     1  MAALKEDRSY GLSCGRVSDG SKVSVFHVKL TDSALRAFES YRARQDSVSL RPSIRFQGSQ
    61  GHISIPQPDC PAEARTFSFY LSNIGRDNPQ GSFDCIQQYV SSHGEVHLDC LGSIQDKITV
   121  CATDDSYQKA RQSMAQAEEE TRSRSAIVIK AGGRYLGKKV QFRKPAPGAT DAVPSRKRAT
   181  PINLASAIRK SGASAVSGGS GVSQRPFRDR VLHLLALRPY RKAELLLRLQ KDGLTQADKD
   241  ALDGLLQQVA NMSAKDGTCT LQDCMYKDVQ KDWPGYSEGD QQLLKRVLVR KLCQPQSTGS
   301  LLGDPAASSP PGERGRSASP PQKRLQPPDF IDPLANKKPR ISHFTQRAQP AVNGKLGVPN
   361  GREALLPTPG PPASTDTLSS STHLPPRLEP PRAHDPLADV SNDLGHSGRD CEHGEAAAPA
   421  PTVRLGLPLL TDCAQPSRPH GSPSRSKPKK KSKKHKDKER AAEDKPRAQL PDCAPATHAT
   481  PGAPADTPGL NGTCSVSSVP TSTSETPDYL LKYAAISSSE QRQSYKNDFN AEYSEYRDLH
   541  ARIERITRRF TQLDAQLRQL SQGSEEYETT RGQILQEYRK IKKTNTNYSQ EKHRCEYLHS
   601  KLAHIKRLIA EYDQRQLQAW P

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ELL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
35 nTPM

Expression across tissuesHPA

Tissue

  • testis: 35 nTPM
  • bone marrow: 28 nTPM
  • skeletal muscle: 19 nTPM
  • spleen: 17 nTPM
  • lung: 16 nTPM
  • skin: 15 nTPM

Single-cell type

  • neutrophils: 458 nCPM
  • early spermatids: 396 nCPM
  • late spermatids: 305 nCPM
  • syncytiotrophoblasts: 209 nCPM
  • endometrial glandular cells: 119 nCPM
  • salivary myoepithelial cells: 109 nCPM

Immune cell

  • neutrophil: 18 nTPM
  • plasmacytoid DC: 8.7 nTPM
  • MAIT T-cell: 7.3 nTPM
  • classical monocyte: 5.9 nTPM
  • myeloid DC: 5 nTPM
  • eosinophil: 4.5 nTPM

Brain region

  • cerebellum: 21 nTPM
  • cerebral cortex: 19 nTPM
  • thalamus: 17 nTPM
  • basal ganglia: 17 nTPM
  • choroid plexus: 14 nTPM
  • medulla oblongata: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.3
gnomAD pLI
0.99
gnomAD missense Z
1.03
DepMap mean gene effect
-1.28
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ELL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ELL as an antibody target. Whether an autoantibody or antibody against ELL could matter depends on whether native ELL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ELL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ELL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ELL. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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