Seroatlas · Human Serome Atlas

ICE2

Little elongation complex subunit 2

Also known as: BRCC1, FLJ11896, ICE2_HUMAN, NARG2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q659A1
Gene
ICE2
Ensembl
ENSG00000128915
Chromosome
15
Canonical length
982 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

This gene encodes a protein component of the little elongation complex (LEC), which plays a role in small nuclear RNA (snRNA) transcription. The LEC regulates snRNA transcription by enhancing both RNA Polymerase II occupancy and transcriptional elongation. The encoded protein and other LEC components have been shown to localize to Cajal bodies, which are sites of ribonucleoprotein (RNP) complex assembly. Pseudogenes of this gene have been identified on chromosomes 3 and 4. [provided by RefSeq, May 2017]

Canonical amino-acid sequenceUniProt

982 residues, UniProt reviewed canonical sequence.

>Q659A1|ICE2
     1  MSSKMVISEP GLNWDISPKN GLKTFFSREN YKDHSMAPSL KELRVLSNRR IGENLNASAS
    61  SVENEPAVSS ATQAKEKVKT TIGMVLLPKP RVPYPRFSRF SQREQRSYVD LLVKYAKIPA
   121  NSKAVGINKN DYLQYLDMKK HVNEEVTEFL KFLQNSAKKC AQDYNMLSDD ARLFTEKILR
   181  ACIEQVKKYS EFYTLHEVTS LMGFFPFRVE MGLKLEKTLL ALGSVKYVKT VFPSMPIKLQ
   241  LSKDDIATIE TSEQTAEAMH YDISKDPNAE KLVSRYHPQI ALTSQSLFTL LNNHGPTYKE
   301  QWEIPVCIQV IPVAGSKPVK VIYINSPLPQ KKMTMRERNQ IFHEVPLKFM MSKNTSVPVS
   361  AVFMDKPEEF ISEMDMSCEV NECRKIESLE NLYLDFDDDV TELETFGVTT TKVSKSPSPA
   421  STSTVPNMTD APTAPKAGTT TVAPSAPDIS ANSRSLSQIL MEQLQKEKQL VTGMDGGPEE
   481  CKNKDDQGFE SCEKVSNSDK PLIQDSDLKT SDALQLENSQ EIETSNKNDM TIDILHADGE
   541  RPNVLENLDN SKEKTVGSEA AKTEDTVLCS SDTDEECLII DTECKNNSDG KTAVVGSNLS
   601  SRPASPNSSS GQASVGNQTN TACSPEESCV LKKPIKRVYK KFDPVGEILK MQDELLKPIS
   661  RKVPELPLMN LENSKQPSVS EQLSGPSDSS SWPKSGWPSA FQKPKGRLPY ELQDYVEDTS
   721  EYLAPQEGNF VYKLFSLQDL LLLVRCSVQR IETRPRSKKR KKIRRQFPVY VLPKVEYQAC
   781  YGVEALTESE LCRLWTESLL HSNSSFYVGH IDAFTSKLFL LEEITSEELK EKLSALKISN
   841  LFNILQHILK KLSSLQEGSY LLSHAAEDSS LLIYKASDGK VTRTAYNLYK THCGLPGVPS
   901  SLSVPWVPLD PSLLLPYHIH HGRIPCTFPP KSLDTTTQQK IGGTRMPTRS HRNPVSMETK
   961  SSCLPAQQVE TEGVAPHKRK IT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ICE2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
33 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 33 nTPM
  • thymus: 12 nTPM
  • tonsil: 9.2 nTPM
  • thyroid gland: 8.7 nTPM
  • lymph node: 8.5 nTPM
  • breast: 7.9 nTPM

Single-cell type

  • myonuclei: 266 nCPM
  • choroid plexus epithelial cells: 114 nCPM
  • corticotrophs: 114 nCPM
  • gonadotrophs: 111 nCPM
  • lactotrophs: 104 nCPM
  • thyrotrophs: 103 nCPM

Immune cell

  • naive B-cell: 11 nTPM
  • MAIT T-cell: 9.7 nTPM
  • naive CD4 T-cell: 9.3 nTPM
  • naive CD8 T-cell: 9.1 nTPM
  • T-reg: 8.1 nTPM
  • memory B-cell: 7.6 nTPM

Brain region

  • white matter: 17 nTPM
  • choroid plexus: 16 nTPM
  • cerebellum: 13 nTPM
  • medulla oblongata: 12 nTPM
  • basal ganglia: 12 nTPM
  • pons: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.84
gnomAD pLI
0
DepMap mean gene effect
-0.49
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Little elongation complex subunit 2 , C-terminal
  • NMDA receptor-regulated gene protein 2 C-terminus

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ICE2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ICE2 as an antibody target. Whether an autoantibody or antibody against ICE2 could matter depends on whether native ICE2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ICE2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ICE2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ICE2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...