ICE1

Protein identityUniProt · HPA

UniProt accession

Q9Y2F5

Gene

ICE1

Ensembl

ENSG00000164151

Chromosome

5

Canonical length

2266 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

Enables protein-macromolecule adaptor activity. Involved in several processes, including positive regulation of intracellular protein transport; positive regulation of transcription by RNA polymerase III; and snRNA transcription. Located in Cajal body; euchromatin; and histone locus body. Part of transcription elongation factor complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

2266 residues, UniProt reviewed canonical sequence.

>Q9Y2F5|ICE1
     1  MMPGETHSAA PGTAADLSRC QGCASLQQNL NEYVEALITL KQKIINTDNL LTEYQKKCDE
    61  LQFARRENSN LHHQVEEMLQ KISPLQKCQE ELGSLKAELE EKKSSLKLYQ DTHQEYARVK
   121  EECLKSDAQK KKLEAKVKKL QEAAVKQTQD FKQLRNEKKI LEKEFKKTQE RLDEFSKQKN
   181  EKELRHIGTQ ISSDSYGSID KRKVKLLLKE LWLCVNTTHR LPGEGSRCVP EKPAKAITSS
   241  RVPGEDGTLP PTQGSPLRTS NVQTCLTKLS MEIKEDFLCQ NVEKQSSSGT NCSSDHVFNE
   301  NGNLEVLVQS HRDGGSTEFV DHDHFFDEDL QAAIDFFKLP PPLLSPVPSP PPMSSPHPGS
   361  LPSSFAPETY FGEYTDSSDN DSVQLRNSAE CVSEDDTTES QNYFGSLRKN KGSGTWEEKP
   421  KSHEAIQALN TWEVNKVTTS GLETFTATLR ESSATHSLVG EKHWTTASRS MSDRKRDILH
   481  ETKTQMEVRE MDKSVQTEKT IHKLTRGLCI ERLSASPAQE KEAAPGKSEL CSSPLGKRPL
   541  NELMESEGKT VLSKMMGSPK SEFTKWTRIN EITSEPDRIT VSGHFHRLSR ELEKEKEDTQ
   601  GFTLGESPES EDDDSGDGMD VAGLDIETSF SSSSTLVALS VGSNPQSSSG LDCGNDTDIT
   661  TKVFSTEPHH SEHKLQTKTL NTLHLQSEPP ECSIGGNNLE NSLCALSPEL GASNFNDQKS
   721  SGIEYTKVVK GLTKIHSLPR SVFMKATKDG QCESQDPRIE LTLNKPDFTS LIGSQAALIK
   781  SGLGFVKSTS WHHSDLLRKG GEESLRAKSE HEQKTSHQLQ KAMPFLQNRG PTPKPDLLRE
   841  NNNPVEFKTT ASVLPNQVSV ITKQTRPEKV QSAKLEHLRP HRVEPTLVTE NSGNKTGMST
   901  VAKCDGERDD TTQNITEVAA VKSISPEVSA SRRKLDFNSP GGSSPVENSD CSTNSRLSFS
   961  PENILIQNQD IVREAAVQGD GQKQRQPQAT DLDSSGTHGS EMLPATEVTV SGGFSVEETS
  1021  CGDTGRSGGE ALAVANDSTS TPQNANGLWK LKSTTPGGAL PECFGTTDTT FSSAFCRKHG
  1081  ETQDTSQSSL PGTLHCYTGI REGGDDTEVE SEAFSCSEGS EQQDAPDDSQ KNLGDTDAAV
  1141  AEVRPSLEVG YLTSALQDFN ISTFSELDRL STSEVVMFLE SCQLGDYSSG DSVSECSSKG
  1201  TLSKEMNKEL KASEIGEKYR KQPCEEETLG TCEEWIESEE DDYSLKNTSQ LTQCSLETLS
  1261  EVLTKIRQEL QTNSEDCNGK DTGSLLLLNV NNNMTTENLK EKSPFRETTG SSSHASEPTP
  1321  QAAALDTEGS SPISGMPQNE NPQSRPEARS DAGRQTDGGE EDLPEPVEPS ALCSDSVMEP
  1381  SIEQSSNCEA ETTFQCQIAT VTSEVINVLI NKDQNLVIEK GDNWTIISGV AVLPHVDQVT
  1441  LCDIPGDIPI SQDQGELEAG CIPVTSAEKS PEASHTGPAF QEAPCGNNLS CPQEDVSSSG
  1501  QSTNFDKSRL RNRPVKPSIW ISSQIYDQNF ETQIVASDHT YYNSKLEPSG KNKNRSKISN
  1561  KDQSNKPVKT SASSRVETHQ SEVAQSFSGE KANTKTQRSQ TQTILANADT STPTDCSPDT
  1621  LSKIRQEVGP PLPPLLAPLI ATPPRTSQPL SPLISSSSPS SPASPVGQVS PFRETPVPPA
  1681  MSPWPEDPRR ASPPDPSPSP SAASASERVV PSPLQFCAAT PKHALPVPGR LPPCASGHAA
  1741  VGGPQENSVK ILDTMYPELS ARARTLNILK GNIQLTRGPP ADCKNLPGPA SAMIGFKTIT
  1801  SAATAFVKTG SSSGGDCNQD KSRDLGTQQD SSGKRTLSTS TLRSAKRLRL DTGSPEPETR
  1861  GVTAEGIHKN LPGNLPPAEV ATTNEERSCS SPAVSAVSQL PLSPKETVES HDKAIANALK
  1921  KIAEFSFDLL PVIRSHVYVG NISKKPVMRD QEKEVVYEFS TTKKHLAECL LHSILSELKI
  1981  QKISMDHNYI HALCRVYVGI CRQLGDLERA RLFCYSLLKE DFPESEKLTL FIANMWHDIF
  2041  LSQSVINKAM QLVARQRAKG EVLNCLRAFL NWEKNAPVDV GFMVSKLLLT IQLCPKTEFQ
  2101  PSEKFGEDLS DNTWEYIFAI DLLCCHQKWI WTHDNIISKE LWPVMDKWIK YRKGHANIAY
  2161  TPDIIIASIL RLIGRLGQLG LKEGFPSAVK NISSVIGMFI QHAHDEDIPW GIQLAAVYAL
  2221  CDLSPSNPAE ISKILEAWRR EASKSVPSAI VSCLEEVSAL STEELG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ICE1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.59

Highest tissue expression

16 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ICE1.

Disease | ImmuneIEDB

Conditions an epitope on ICE1 was assayed in.

• pancreatic ductal adenocarcinoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.16

gnomAD pLI

1

DepMap mean gene effect

-0.81

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• positive regulation of intracellular protein transport
• positive regulation of protein-containing complex assembly
• positive regulation of transcription by RNA polymerase III
• snRNA transcription by RNA polymerase II
• snRNA transcription by RNA polymerase III

Molecular functions

• protein-macromolecule adaptor activity

Cellular components

• Cajal body
• euchromatin
• histone locus body
• nuclear body
• nucleoplasm
• transcription elongation factor complex

Protein domainsUniProt · Pfam · InterPro

• Little elongation complex subunit 1, C-terminal domain
• Little elongation complex subunit 1, C-terminal domain

KeywordsUniProt

• Acetylation
• Coiled coil
• Nucleus
• Phosphoprotein
• Transcription
• Transcription regulation

InteractionsUniProt · HPA

Protein binding partners of ICE1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ICE2
• ZC3H8
• ELL
• EAF1