Seroatlas · Human Serome Atlas

MLLT1

Protein ENL

Also known as: ENL, ENL_HUMAN, LTG19, YEATS1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q03111
Gene
MLLT1
Ensembl
ENSG00000130382
Chromosome
19
Canonical length
559 aa
Protein class
Cancer-related genes, Disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli fibrillar center

OverviewNCBI Gene

Predicted to enable chromatin binding activity and lysine-acetylated histone binding activity. Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to act upstream of or within negative regulation of protein kinase activity. Located in cytosol; fibrillar center; and nucleoplasm. Part of transcription elongation factor complex. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

559 residues, UniProt reviewed canonical sequence.

>Q03111|MLLT1
     1  MDNQCTVQVR LELGHRAQLR KKPTTEGFTH DWMVFVRGPE QCDIQHFVEK VVFWLHDSFP
    61  KPRRVCKEPP YKVEESGYAG FIMPIEVHFK NKEEPRKVCF TYDLFLNLEG NPPVNHLRCE
   121  KLTFNNPTTE FRYKLLRAGG VMVMPEGADT VSRPSPDYPM LPTIPLSAFS DPKKTKPSHG
   181  SKDANKESSK TSKPHKVTKE HRERPRKDSE SKSSSKELER EQAKSSKDTS RKLGEGRLPK
   241  EEKAPPPKAA FKEPKMALKE TKLESTSPKG GPPPPPPPPP RASSKRPATA DSPKPSAKKQ
   301  KKSSSKGSRS APGTSPRTSS SSSFSDKKPA KDKSSTRGEK VKAESEPREA KKALEVEESN
   361  SEDEASFKSE SAQSSPSNSS SSSDSSSDSD FEPSQNHSQG PLRSMVEDLQ SEESDEDDSS
   421  SGEEAAGKTN PGRDSRLSFS DSESDNSADS SLPSREPPPP QKPPPPNSKV SGRRSPESCS
   481  KPEKILKKGT YDKAYTDELV ELHRRLMALR ERNVLQQIVN LIEETGHFNV TNTTFDFDLF
   541  SLDETTVRKL QSCLEAVAT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MLLT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
69 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 69 nTPM
  • cerebral cortex: 54 nTPM
  • basal ganglia: 47 nTPM
  • ovary: 45 nTPM
  • hippocampal formation: 42 nTPM
  • placenta: 40 nTPM

Single-cell type

  • syncytiotrophoblasts: 1,341 nCPM
  • cytotrophoblasts: 697 nCPM
  • migrating cytotrophoblasts: 328 nCPM
  • epididymal efferent duct ciliated cells: 134 nCPM
  • fallopian tube ciliated cells: 107 nCPM
  • neutrophils: 103 nCPM

Immune cell

  • neutrophil: 2 nTPM
  • plasmacytoid DC: 2 nTPM
  • non-classical monocyte: 1.5 nTPM
  • intermediate monocyte: 1.2 nTPM
  • MAIT T-cell: 0.9 nTPM
  • classical monocyte: 0.8 nTPM

Brain region

  • cerebral cortex: 90 nTPM
  • hippocampal formation: 87 nTPM
  • amygdala: 81 nTPM
  • cerebellum: 78 nTPM
  • basal ganglia: 76 nTPM
  • thalamus: 75 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MLLT1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 80 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.29
gnomAD pLI
0.99
gnomAD missense Z
2.69
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MLLT1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MLLT1 as an antibody target. Whether an autoantibody or antibody against MLLT1 could matter depends on whether native MLLT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MLLT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MLLT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MLLT1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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