Seroatlas · Human Serome Atlas

CDC123

Translation initiation factor eIF2 assembly protein

Also known as: C10orf7, CD123_HUMAN, D123

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75794
Gene: CDC123
Ensembl: ENSG00000151465
Chromosome: 10
Canonical length: 336 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Cytosol

OverviewNCBI Gene

Enables ATP binding activity and magnesium ion binding activity. Involved in eukaryotic translation initiation factor 2 complex assembly. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

336 residues, UniProt reviewed canonical sequence.

>O75794|CDC123
     1  MKKEHVLHCQ FSAWYPFFRG VTIKSVILPL PQNVKDYLLD DGTLVVSGRD DPPTHSQPDS
    61  DDEAEEIQWS DDENTATLTA PEFPEFATKV QEAINSLGGS VFPKLNWSAP RDAYWIAMNS
   121  SLKCKTLSDI FLLFKSSDFI TRDFTQPFIH CTDDSPDPCI EYELVLRKWC ELIPGAEFRC
   181  FVKENKLIGI SQRDYTQYYD HISKQKEEIR RCIQDFFKKH IQYKFLDEDF VFDIYRDSRG
   241  KVWLIDFNPF GEVTDSLLFT WEELISENNL NGDFSEVDAQ EQDSPAFRCT NSEVTVQPSP
   301  YLSYRLPKDF VDLSTGEDAH KLIDFLKLKR NQQEDD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDC123 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 76 nTPM

Expression across tissuesHPA

Tissue

tonsil: 76 nTPM
bone marrow: 69 nTPM
lymph node: 65 nTPM
thymus: 61 nTPM
urinary bladder: 59 nTPM
heart muscle: 58 nTPM

Single-cell type

neutrophils: 606 nCPM
oocytes: 198 nCPM
extravillous trophoblasts: 179 nCPM
hofbauer cells: 166 nCPM
migrating cytotrophoblasts: 162 nCPM
cytotrophoblasts: 155 nCPM

Immune cell

eosinophil: 243 nTPM
neutrophil: 235 nTPM
naive B-cell: 172 nTPM
total PBMC: 168 nTPM
memory B-cell: 159 nTPM
T-reg: 144 nTPM

Brain region

basal ganglia: 46 nTPM
white matter: 46 nTPM
cerebral cortex: 42 nTPM
hypothalamus: 41 nTPM
spinal cord: 40 nTPM
cerebellum: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.81
gnomAD pLI: 0
gnomAD missense Z: 1.1
DepMap mean gene effect: -1.87
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

eukaryotic translation initiation factor 2 complex assembly

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

Cell division cycle protein 123
D123

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CDC123 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDC123 as an antibody target. Whether an autoantibody or antibody against CDC123 could matter depends on whether native CDC123 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDC123 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDC123 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...