Seroatlas · Human Serome Atlas

EIF2B2

Translation initiation factor eIF2B subunit beta

Also known as: EI2BB_HUMAN, EIF-2Bbeta, EIF2B, EIF2Bbeta

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P49770
Gene
EIF2B2
Ensembl
ENSG00000119718
Chromosome
14
Canonical length
351 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Plasma membrane,Focal adhesion sites

OverviewNCBI Gene

This gene encodes the beta subunit of eukaryotic initiation factor-2B (EIF2B). EIF2B is involved in protein synthesis and exchanges GDP and GTP for its activation and deactivation. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

351 residues, UniProt reviewed canonical sequence.

>P49770|EIF2B2
     1  MPGSAAKGSE LSERIESFVE TLKRGGGPRS SEEMARETLG LLRQIITDHR WSNAGELMEL
    61  IRREGRRMTA AQPSETTVGN MVRRVLKIIR EEYGRLHGRS DESDQQESLH KLLTSGGLNE
   121  DFSFHYAQLQ SNIIEAINEL LVELEGTMEN IAAQALEHIH SNEVIMTIGF SRTVEAFLKE
   181  AARKRKFHVI VAECAPFCQG HEMAVNLSKA GIETTVMTDA AIFAVMSRVN KVIIGTKTIL
   241  ANGALRAVTG THTLALAAKH HSTPLIVCAP MFKLSPQFPN EEDSFHKFVA PEEVLPFTEG
   301  DILEKVSVHC PVFDYVPPEL ITLFISNIGG NAPSYIYRLM SELYHPDDHV L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EIF2B2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
11 nTPM

Expression across tissuesHPA

Tissue

  • thyroid gland: 11 nTPM
  • parathyroid gland: 8 nTPM
  • tongue: 6.6 nTPM
  • retina: 6.2 nTPM
  • skeletal muscle: 5.4 nTPM
  • adrenal gland: 5 nTPM

Single-cell type

  • syncytiotrophoblasts: 245 nCPM
  • late primary spermatocytes: 112 nCPM
  • extravillous trophoblasts: 68 nCPM
  • esophageal suprabasal cells: 65 nCPM
  • cytotrophoblasts: 61 nCPM
  • migrating cytotrophoblasts: 55 nCPM

Immune cell

  • basophil: 4.2 nTPM
  • T-reg: 4 nTPM
  • NK-cell: 3.3 nTPM
  • gdT-cell: 3 nTPM
  • memory CD4 T-cell: 2.6 nTPM
  • MAIT T-cell: 2.5 nTPM

Brain region

  • cerebellum: 26 nTPM
  • white matter: 21 nTPM
  • hypothalamus: 21 nTPM
  • cerebral cortex: 18 nTPM
  • thalamus: 18 nTPM
  • medulla oblongata: 17 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about EIF2B2.

Disease | AllUniProt

Conditions EIF2B2 is implicated in, by any mechanism.

  • Leukoencephalopathy with vanishing white matter 2 (VWM2) MIM:620312

Disease | GeneticClinVar

39 pathogenic / likely-pathogenic of 345 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.52
gnomAD pLI
0
gnomAD missense Z
1.03
DepMap mean gene effect
-1.56
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EIF2B2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EIF2B2 as an antibody target. Whether an autoantibody or antibody against EIF2B2 could matter depends on whether native EIF2B2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EIF2B2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EIF2B2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EIF2B2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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