W2 domain

Definition

Translation initiation is a sophisticated, well regulated and highly coordinated cellular process in eukaryotes, in which at least 11 eukaryotic initiation factors (eIFs) are included. The W2 domain (two invariant tryptophans) is a region of ~165 amino acids which is found in the C terminus of the following eIFs [[cite:PMID:8520487], [cite:PMID:10958635], [cite:PMID:14681227], [cite:PMID:16616930], [cite:PMID:16781736]]: Eukaryotic translation initiation factor 2B epsilon (eIF-2B-epsilon). Eukaryotic translation initiation factor 4 gamma (eIF-4-gamma). Eukaryotic translation initiation factor 5 (eIF-5), a GTPase-activating protein (GAP) specific for eIF2. The W2 domain has a globular fold and is exclusively composed out of α-helices [[cite:PMID:14681227], [cite:PMID:16616930], [cite:PMID:16781736]]. The structure can be divided into a structural C-terminal core onto which the two N-terminal helices are attached. The core contains two aromatic/acidic residue-rich regions (AA boxes), which are important for mediating protein-protein interactions.

7 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (7 proteins: gene, accession, name)

• BZW1
• BZW2
• EIF2B5
• EIF4G1
• EIF4G2
• EIF4G3
• EIF5