EEF1B2

Protein identityUniProt · HPA

UniProt accession

P24534

Gene

EEF1B2

Ensembl

ENSG00000114942

Chromosome

2

Canonical length

225 aa

Protein class

Plasma proteins, Predicted intracellular proteins

Subcellular location

Nucleoli fibrillar center,Cytosol

OverviewNCBI Gene

This gene encodes a translation elongation factor. The protein is a guanine nucleotide exchange factor involved in the transfer of aminoacylated tRNAs to the ribosome. Alternative splicing results in three transcript variants which differ only in the 5' UTR. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

225 residues, UniProt reviewed canonical sequence.

>P24534|EEF1B2
     1  MGFGDLKSPA GLQVLNDYLA DKSYIEGYVP SQADVAVFEA VSSPPPADLC HALRWYNHIK
    61  SYEKEKASLP GVKKALGKYG PADVEDTTGS GATDSKDDDD IDLFGSDDEE ESEEAKRLRE
   121  ERLAQYESKK AKKPALVAKS SILLDVKPWD DETDMAKLEE CVRSIQADGL VWGSSKLVPV
   181  GYGIKKLQIQ CVVEDDKVGT DMLEEQITAF EDYVQSMDVA AFNKI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EEF1B2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.38

Highest tissue expression

1,748 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about EEF1B2.

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 40 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Global developmental delay
• Intellectual disability
• Moderate global developmental delay
• Seizure

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.75

gnomAD pLI

0.07

gnomAD missense Z

0.33

DepMap mean gene effect

-0.85

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• response to ethanol
• translational elongation

Molecular functions

• guanyl-nucleotide exchange factor activity
• translation elongation factor activity

Cellular components

• cytoplasm
• cytosol
• eukaryotic translation elongation factor 1 complex

Protein domainsUniProt · Pfam · InterPro

• Translation elongation factor EF1B, beta/delta chains, conserved site
• Translation elongation factor EF1B, beta/delta subunit, guanine nucleotide exchange domain
• Translation elongation factor EF1B/small ribosomal subunit protein bS6
• Elongation factor 1 beta central acidic region, eukaryote
• Translation elongation factor eEF-1beta-like superfamily
• Glutathione S-transferase, C-terminal domain superfamily
• Translation elongation factor EF1B, beta/delta subunit
• EF-1 guanine nucleotide exchange domain
• Eukaryotic elongation factor 1 beta central acidic region

KeywordsUniProt

• Acetylation
• Elongation factor
• Isopeptide bond
• Phosphoprotein
• Protein biosynthesis
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of EEF1B2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• EEF1A1
• EEF1A2
• EEF1G