Serine/threonine and dual-specificity kinase
IPR050494
Definition
This family of proteins includes serine/threonine and dual-specificity kinases that play roles in various cellular processes, including cell cycle regulation, DNA damage repair, transcription regulation, apoptosis, and cytoskeletal organization. Some members are involved in pre-mRNA splicing and stress responses, while others function in developmental processes such as neuronal growth, eye size regulation, and erythroid differentiation. These kinases can phosphorylate a range of substrates, including transcription factors, histones, and other kinases, influencing their activity, stability, and localization. They are also implicated in signaling pathways related to stress granule dynamics, mTORC1 signaling, and proteasomal degradation of key regulatory proteins.
10 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
Loading the interactive Seroatlas explorer...