BCL7B

Protein identityUniProt · HPA

UniProt accession

Q9BQE9

Gene

BCL7B

Ensembl

ENSG00000106635

Chromosome

7

Canonical length

202 aa

Protein class

Disease related genes, Human disease related genes, Predicted intracellular proteins

Subcellular location

Nucleoplasm

OverviewNCBI Gene

This gene encodes a member of the BCL7 family including BCL7A, BCL7B and BCL7C proteins. This member is BCL7B, which contains a region that is highly similar to the N-terminal segment of BCL7A or BCL7C proteins. The BCL7A protein is encoded by the gene known to be directly involved in a three-way gene translocation in a Burkitt lymphoma cell line. This gene is located at a chromosomal region commonly deleted in Williams syndrome. This gene is highly conserved from C. elegans to human. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2010]

Canonical amino-acid sequenceUniProt

202 residues, UniProt reviewed canonical sequence.

>Q9BQE9|BCL7B
     1  MSGRSVRAET RSRAKDDIKK VMAAIEKVRK WEKKWVTVGD TSLRIFKWVP VTDSKEKEKS
    61  KSNSSAAREP NGFPSDASAN SSLLLEFQDE NSNQSSVSDV YQLKVDSSTN SSPSPQQSES
   121  LSPAHTSDFR TDDSQPPTLG QEILEEPSLP SSEVADEPPT LTKEEPVPLE TQVVEEEEDS
   181  GAPPLKRFCV DQPTVPQTAS ES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BCL7B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.67

Highest tissue expression

97 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.71

gnomAD pLI

0.19

gnomAD missense Z

1.22

DepMap mean gene effect

0.02

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• apoptotic process
• cell differentiation
• chromatin remodeling
• negative regulation of cell differentiation
• positive regulation of cell population proliferation
• positive regulation of double-strand break repair
• positive regulation of stem cell population maintenance
• regulation of G0 to G1 transition
• regulation of G1/S transition of mitotic cell cycle
• regulation of mitotic metaphase/anaphase transition
• regulation of nucleotide-excision repair
• regulation of transcription by RNA polymerase II
• Wnt signaling pathway

Molecular functions

• actin binding

Cellular components

• chromatin
• GBAF complex
• nucleoplasm
• SWI/SNF complex

Protein domainsUniProt · Pfam · InterPro

• BCL7
• BCL7, N-terminal conserver region

KeywordsUniProt

• Allergen
• Apoptosis
• Differentiation
• Phosphoprotein
• Williams-Beuren syndrome
• Wnt signaling pathway

InteractionsUniProt · HPA

Protein binding partners of BCL7B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• DPF2
• SMARCA4