Seroatlas · Human Serome Atlas

SESTD1

SEC14 domain and spectrin repeat-containing protein 1

Also known as: DKFZp434O0515, SESD1_HUMAN, Solo

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86VW0
Gene
SESTD1
Ensembl
ENSG00000187231
Chromosome
2
Canonical length
696 aa
Protein class
Predicted intracellular proteins
Subcellular location
Intermediate filaments

OverviewNCBI Gene

Enables phosphatidylinositol-3,4-bisphosphate binding activity and phospholipid binding activity. Involved in negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel. Located in calcium channel complex and intermediate filament cytoskeleton. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

696 residues, UniProt reviewed canonical sequence.

>Q86VW0|SESTD1
     1  MEASVILPIL KKKLAFLSGG KDRRSGLILT IPLCLEQTNM DELSVTLDYL LSIPSEKCKA
    61  RGFTVIVDGR KSQWNVVKTV VVMLQNVVPA EVSLVCVVKP DEFWDKKVTH FCFWKEKDRL
   121  GFEVILVSAN KLTRYIEPCQ LTEDFGGSLT YDHMDWLNKR LVFEKFTKES TSLLDELALI
   181  NNGSDKGNQQ EKERSVDLNF LPSVDPETVL QTGHELLSEL QQRRFNGSDG GVSWSPMDDE
   241  LLAQPQVMKL LDSLREQYTR YQEVCRQRSK RTQLEEIQQK VMQVVNWLEG PGSEQLRAQW
   301  GIGDSIRASQ ALQQKHEEIE SQHSEWFAVY VELNQQIAAL LNAGDEEDLV ELKSLQQQLS
   361  DVCYRQASQL EFRQNLLQAA LEFHGVAQDL SQQLDGLLGM LCVDVAPADG ASIQQTLKLL
   421  EEKLKSVDVG LQGLREKGQG LLDQISNQAS WAYGKDVTIE NKENVDHIQG VMEDMQLRKQ
   481  RCEDMVDVRR LKMLQMVQLF KCEEDAAQAV EWLSELLDAL LKTHIRLGDD AQETKVLLEK
   541  HRKFVDVAQS TYDYGRQLLQ ATVVLCQSLR CTSRSSGDTL PRLNRVWKQF TIASEERVHR
   601  LEMAIAFHSN AEKILQDCPE EPEAINDEEQ FDEIEAVGKS LLDRLTVPVV YPDGTEQYFG
   661  SPSDMASTAE NIRDRMKLVN LKRQQLRHPE MVTTES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SESTD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
15 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 15 nTPM
  • adipose tissue: 14 nTPM
  • spinal cord: 13 nTPM
  • breast: 10 nTPM
  • salivary gland: 10 nTPM
  • urinary bladder: 8.9 nTPM

Single-cell type

  • endometrial glandular cells: 950 nCPM
  • retinal horizontal cells: 803 nCPM
  • endometrial luminal cells: 757 nCPM
  • monocytes: 582 nCPM
  • adipocytes: 409 nCPM
  • salivary acinar cells: 392 nCPM

Immune cell

  • non-classical monocyte: 1.6 nTPM
  • naive B-cell: 1.5 nTPM
  • memory B-cell: 1.2 nTPM
  • classical monocyte: 0.9 nTPM
  • intermediate monocyte: 0.7 nTPM
  • myeloid DC: 0.4 nTPM

Brain region

  • white matter: 62 nTPM
  • thalamus: 53 nTPM
  • basal ganglia: 50 nTPM
  • medulla oblongata: 49 nTPM
  • spinal cord: 48 nTPM
  • midbrain: 43 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.27
gnomAD pLI
1
gnomAD missense Z
2.31
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SESTD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SESTD1 as an antibody target. Whether an autoantibody or antibody against SESTD1 could matter depends on whether native SESTD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SESTD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SESTD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SESTD1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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