Seroatlas · Human Serome Atlas

VANGL2

Vang-like protein 2

Also known as: KIAA1215, LPP1, LTAP, MGC119403, MGC119404, STB1, STBM, STBM1, VANG2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9ULK5
Gene
VANGL2
Ensembl
ENSG00000162738
Chromosome
1
Canonical length
521 aa
Protein class
Disease related genes, Human disease related genes, Predicted membrane proteins
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a membrane protein involved in the regulation of planar cell polarity, especially in the stereociliary bundles of the cochlea. The encoded protein transmits directional signals to individual cells or groups of cells in epithelial sheets. This protein is also involved in the development of the neural plate. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

521 residues, UniProt reviewed canonical sequence.

>Q9ULK5|VANGL2
     1  MDTESQYSGY SYKSGHSRSS RKHRDRRDRH RSKSRDGGRG DKSVTIQAPG EPLLDNESTR
    61  GDERDDNWGE TTTVVTGTSE HSISHDDLTR IAKDMEDSVP LDCSRHLGVA AGATLALLSF
   121  LTPLAFLLLP PLLWREELEP CGTACEGLFI SVAFKLLILL LGSWALFFRR PKASLPRVFV
   181  LRALLMVLVF LLVVSYWLFY GVRILDARER SYQGVVQFAV SLVDALLFVH YLAVVLLELR
   241  QLQPQFTLKV VRSTDGASRF YNVGHLSIQR VAVWILEKYY HDFPVYNPAL LNLPKSVLAK
   301  KVSGFKVYSL GEENSTNNST GQSRAVIAAA ARRRDNSHNE YYYEEAEHER RVRKRRARLV
   361  VAVEEAFTHI KRLQEEEQKN PREVMDPREA AQAIFASMAR AMQKYLRTTK QQPYHTMESI
   421  LQHLEFCITH DMTPKAFLER YLAAGPTIQY HKERWLAKQW TLVSEEPVTN GLKDGIVFLL
   481  KRQDFSLVVS TKKVPFFKLS EEFVDPKSHK FVMRLQSETS V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VANGL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
36 nTPM

Expression across tissuesHPA

Tissue

  • skin: 36 nTPM
  • cerebellum: 13 nTPM
  • vagina: 13 nTPM
  • salivary gland: 13 nTPM
  • esophagus: 12 nTPM
  • cervix: 11 nTPM

Single-cell type

  • tuft cells: 35 nCPM
  • pituitary stem cells: 34 nCPM
  • prostatic hillock cells: 26 nCPM
  • cone photoreceptor cells: 25 nCPM
  • astrocytes: 24 nCPM
  • ependymal cells: 22 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • midbrain: 29 nTPM
  • hypothalamus: 26 nTPM
  • medulla oblongata: 25 nTPM
  • spinal cord: 25 nTPM
  • pons: 21 nTPM
  • white matter: 20 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about VANGL2.

Disease | AllUniProt

Conditions VANGL2 is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.39
gnomAD pLI
0.84
gnomAD missense Z
1.43
DepMap mean gene effect
-0.16
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of VANGL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VANGL2 as an antibody target. Whether an autoantibody or antibody against VANGL2 could matter depends on whether native VANGL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VANGL2 is annotated at the cell surface, where native VANGL2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label VANGL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/VANGL2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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