Seroatlas · Human Serome Atlas

IPCEF1

Interactor protein for cytohesin exchange factors 1

Also known as: ICEF1_HUMAN, KIAA0403, PIP3-E

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WWN9
Gene
IPCEF1
Ensembl
ENSG00000074706
Chromosome
6
Canonical length
437 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoli,Nuclear speckles,Plasma membrane,Cytoplasmic bodies

OverviewNCBI Gene

Predicted to enable peroxidase activity. Predicted to be involved in response to oxidative stress. Predicted to be located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

437 residues, UniProt reviewed canonical sequence.

>Q8WWN9|IPCEF1
     1  MTSYMAIDGS ALVPLRQKPR RKTQGFLTMS RRRISCKDLG HADCQGWLYK KKEKGSFLSN
    61  KWKKFWVILK GSSLYWYSNQ MAEKADGFVN LPDFTVERAS ECKKKHAFKI SHPQIKTFYF
   121  AAENVQEMNV WLNKLGSAVI HQESTTKDEE CYSESEQEDP EIAAETPPPP HASQTQSLTA
   181  QQASSSSPSL SGTSYSFSSL ENTVKTPSSF PSSLSKERQS LPDTVNSLSA AEDEGQPITF
   241  AVQVHSPVPS EAGIHKALEN SFVTSESGFL NSLSSDDTSS LSSNHDHLTV PDKPAGSKIM
   301  DKEETKVSED DEMEKLYKSL EQASLSPLGD RRPSTKKELR KSFVKRCKNP SINEKLHKIR
   361  TLNSTLKCKE HDLAMINQLL DDPKLTARKY REWKVMNTLL IQDIYQQQRA SPAPDDTDDT
   421  PQELKKSPSS PSVENSI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IPCEF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
34 nTPM

Expression across tissuesHPA

Tissue

  • thyroid gland: 34 nTPM
  • cerebral cortex: 18 nTPM
  • bone marrow: 16 nTPM
  • cerebellum: 14 nTPM
  • lymph node: 13 nTPM
  • tonsil: 12 nTPM

Single-cell type

  • renal collecting duct intercalated cells: 346 nCPM
  • renal connecting tubule cells: 299 nCPM
  • distal convoluted tubule cells: 283 nCPM
  • loop of henle epithelial cells: 179 nCPM
  • renal collecting duct principal cells: 105 nCPM
  • neutrophil progenitors: 67 nCPM

Immune cell

  • eosinophil: 53 nTPM
  • neutrophil: 30 nTPM
  • naive CD4 T-cell: 28 nTPM
  • MAIT T-cell: 28 nTPM
  • T-reg: 23 nTPM
  • naive CD8 T-cell: 17 nTPM

Brain region

  • cerebral cortex: 56 nTPM
  • thalamus: 42 nTPM
  • basal ganglia: 41 nTPM
  • white matter: 39 nTPM
  • midbrain: 35 nTPM
  • cerebellum: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.66
gnomAD pLI
0
gnomAD missense Z
1.23
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IPCEF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IPCEF1 as an antibody target. Whether an autoantibody or antibody against IPCEF1 could matter depends on whether native IPCEF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IPCEF1 is annotated at the cell surface, where native IPCEF1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IPCEF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IPCEF1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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