MBP

Protein identityUniProt · HPA

UniProt accession

P02686

Gene

MBP

Ensembl

ENSG00000197971

Chromosome

18

Canonical length

304 aa

Protein class

Candidate cardiovascular disease genes, Disease related genes, Plasma proteins, Predicted intracellular proteins

Subcellular location

Plasma membrane

Quaternary structure

Homodimer

OverviewNCBI Gene

The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called """"""""""""""""""""""""""""""""Golli-MBP"""""""""""""""""""""""""""""""") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

304 residues, UniProt reviewed canonical sequence.

>P02686|MBP
     1  MGNHAGKREL NAEKASTNSE TNRGESEKKR NLGELSRTTS EDNEVFGEAD ANQNNGTSSQ
    61  DTAVTDSKRT ADPKNAWQDA HPADPGSRPH LIRLFSRDAP GREDNTFKDR PSESDELQTI
   121  QEDSAATSES LDVMASQKRP SQRHGSKYLA TASTMDHARH GFLPRHRDTG ILDSIGRFFG
   181  GDRGAPKRGS GKDSHHPART AHYGSLPQKS HGRTQDENPV VHFFKNIVTP RTPPPSQGKG
   241  RGLSLSRFSW GAEGQRPGFG YGGRASDYKS AHKGFKGVDA QGTLSKIFKL GGRDSRSGSP
   301  MARR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MBP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.69

Highest tissue expression

89,103 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MBP.

Disease | ImmuneIEDB

Conditions an epitope on MBP was assayed in.

• multiple sclerosis B and T cell
• localized scleroderma B cell
• infectious mononucleosis B and T cell
• encephalomyelitis B cell
• autoimmune optic neuritis B cell
• amyotrophic lateral sclerosis B cell
• systemic lupus erythematosus B cell
• autoimmune neuropathy T cell

Disease | AutoantibodyPubMed

Conditions in which antibodies against MBP are reported. Each links to that disease's full target list.

• Multiple Sclerosis 78
• Encephalomyelitis, Autoimmune, Experimental 41
• Hypersensitivity, Delayed 4
• Arthritis, Rheumatoid 3
• Peripheral Nervous System Diseases 3
• Schizophrenia 3
• Stroke 3

Showing 7 of 11 — disease pages carrying at least 10 antigens.

ReferencesPubMed · IEDB

Publications for MBP from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.79

gnomAD pLI

0.28

gnomAD missense Z

0.6

DepMap mean gene effect

0.1

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• axon ensheathment
• central nervous system development
• chemical synaptic transmission
• immune response
• membrane organization
• myelin assembly
• myelination
• response to toxic substance
• sensory perception of sound

Molecular functions

• calmodulin binding
• lipid binding
• protease binding
• structural constituent of myelin sheath

Cellular components

• cell periphery
• cell surface
• compact myelin
• cytosol
• internode region of axon
• myelin sheath
• neuronal cell body
• nucleus
• protein-containing complex
• synapse

Protein domainsUniProt · Pfam · InterPro

• Myelin basic protein
• Myelin basic protein

KeywordsUniProt

• Acetylation
• Cell membrane
• Citrullination
• Membrane
• Methylation
• Nucleus
• Phosphoprotein
• Autoimmune encephalomyelitis

InteractionsUniProt · HPA

Protein binding partners of MBP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ADRB2
• CCR1
• CTDSP1
• PTAFR