Mitochondrial import inner membrane translocase subunit TIM50

Definition

The TIM50 family proteins are essential components of the TIM23 complex, which mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. These proteins are required to direct preproteins in transit to the channel protein TIM23 and may facilitate the transfer of translocating proteins from the TOM complex to the TIM23 complex. Although some members have phosphatase activity in vitro, this activity may not be relevant in vivo. The TIM50 family plays a dynamic role in protein import and does not act as a structural subunit of the TIM23 complex.

6 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (6 proteins: gene, accession, name)

• CTDNEP1
• CTDSP1
• CTDSP2
• CTDSPL
• CTDSPL2
• TIMM50