Seroatlas · Human Serome Atlas

CEP162

Centrosomal protein of 162 kDa

Also known as: C6orf84, CE162_HUMAN, KIAA1009, QN1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5TB80
Gene: CEP162
Ensembl: ENSG00000135315
Chromosome: 6
Canonical length: 1403 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Centriolar satellite,Basal body,Cytosol,Connecting piece,Mid piece,Principal piece

OverviewNCBI Gene

Involved in cilium assembly. Located in several cellular components, including Golgi apparatus; microtubule cytoskeleton; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1403 residues, UniProt reviewed canonical sequence.

>Q5TB80|CEP162
     1  MANCSQEELD EEFEQFMKEL SDDSFENSDK TARQSKKEMK KKDTVPWWIT EDDFKDDGLL
    61  GTNVSYLKTK KTSQPVMEIE EESAEKIQFL KSSGTSLLST DSLETNELVV SELNHSSLGV
   121  GLDTLEEQEE KEQFFARLEK GLTSSIDYSR LNKELDSNDS THFKALHSNQ ANAELTDDEH
   181  ENESKHEELA ENYSDDFEDE YVGAPLTTKD EEMPSKENSK SEKISVPKQE EEKTGMLANV
   241  VLLDSLDSVA EVNLDEQDKI TPKPRCLPEM TENEMTGTGV SYGQSSSDVE ALHQAYCHIA
   301  HSLGDEDKQK IESNTVEDIK SSVKGHPQEN EENSKNISTM ESDLPTVEEL MKPIRIDSFG
   361  ISGFDLQPVS SEKVAERKET EFFSSLPLKM NPNILSQDSQ HVNLFFDKND ENVILQKTTN
   421  ESMENSCPQV TEVTATEEHV DKMYLNILRK KITVNSSSLS QDDKINKTYR SQLSSEEEGA
   481  VMGKQVPYKK ARSAPPLLKR KPQSGLYASV RSSGYGKPSS PLKMFSTLEK KTSEDIIKSK
   541  NLRSISTSNQ PRKKEILSGT KLIKPAALDK PAHKTESCLS TRKKSENPTE TDSCIQFQTD
   601  SLGYCGENKE KKLLMFKRVQ EAEDKWRGAQ ALIEQIKATF SEKEKELENK LEELKKQQEK
   661  ELFKLNQDNY ILQAKLSSFE ETNKKQRWLH FGEAADPVTG EKLKQIQKEI QEQETLLQGY
   721  QQENERLYNQ VKDLQEQNKK NEERMFKENQ SLFSEVASLK EQMHKSRFLS QVVEDSEPTR
   781  NQNFTDLLAE LRMAQKEKDS LLEDIKRLKQ DKQALEVDFE KMKKERDQAK DQIAYVTGEK
   841  LYEIKILEET HKQEISRLQK RLQWYAENQE LLDKDALRLR EANEEIEKLK LEIEKLKAES
   901  GNPSIRQKIR LKDKAADAKK IQDLERQVKE MEGILKRRYP NSLPALILAA SAAGDTVDKN
   961  TVEFMEKRIK KLEADLEGKD EDAKKSLRTM EQQFQKMKIQ YEQRLEQQEQ LLACKLNQHD
  1021  SPRIKALEKE LDDIKEAHQI TVRNLEAEID VLKHQNAELD VKKNDKDDED FQSIEFQVEQ
  1081  AHAKAKLVRL NEELAAKKRE IQDLSKTVER LQKDRRMMLS NQNSKGREEM SAKRAKKDVL
  1141  HSSKGNANSF PGTLDSKLYQ PHTFTDSHVS EVLQENYRLK NELEGLISEK NELKMKSEAV
  1201  MNQFENSMRR VKEDTAAHIA SLKASHQREI EKLLCQNAVE NSSSKVAELN RKIATQEVLI
  1261  RHFQSQVNEL QSKQESLVVS EVREEILQKE ITKLLEELRE AKENHTPEMK HFVGLEKKIK
  1321  QMEMRHAQRE QELQQIIQQT HQVVETEQNK EVEKWKRLAQ LKNRELEKFR TELDSILDVL
  1381  RELHRQGVVV PVAFADEMNA PEY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CEP162 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 8 nTPM

Expression across tissuesHPA

Tissue

testis: 8 nTPM
parathyroid gland: 4 nTPM
thymus: 3.6 nTPM
endometrium: 3.5 nTPM
fallopian tube: 3.5 nTPM
ovary: 3.3 nTPM

Single-cell type

early spermatids: 193 nCPM
late primary spermatocytes: 188 nCPM
ependymal cells: 173 nCPM
respiratory ciliated cells: 155 nCPM
choroid plexus epithelial cells: 136 nCPM
fallopian tube ciliated cells: 102 nCPM

Immune cell

MAIT T-cell: 0.5 nTPM
memory B-cell: 0.5 nTPM
neutrophil: 0.5 nTPM
gdT-cell: 0.4 nTPM
naive CD8 T-cell: 0.4 nTPM
plasmacytoid DC: 0.4 nTPM

Brain region

choroid plexus: 12 nTPM
white matter: 11 nTPM
basal ganglia: 8.7 nTPM
cerebellum: 8.5 nTPM
midbrain: 8.3 nTPM
cerebral cortex: 8.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.98
gnomAD pLI: 0
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cilium assembly

Cellular components

Protein domainsUniProt · Pfam · InterPro

Centrosomal protein CEP162-like

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CEP162 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CEP162 as an antibody target. Whether an autoantibody or antibody against CEP162 could matter depends on whether native CEP162 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CEP162 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CEP162 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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