Seroatlas · Human Serome Atlas

KIAA1217

Sickle tail protein homolog

Also known as: DKFZP761L0424, ETL4, SKT, SKT_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T5P2
Gene: KIAA1217
Ensembl: ENSG00000120549
Chromosome: 10
Canonical length: 1943 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to be involved in embryonic skeletal system development. Located in centrosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1943 residues, UniProt reviewed canonical sequence.

>Q5T5P2|KIAA1217
     1  MEENESQKCE PCLPYSADRR QMQEQGKGNL HVTSPEDAEC RRTKERLSNG NSRGSVSKSS
    61  RNIPRRHTLG GPRSSKEILG MQTSEMDRKR EAFLEHLKQK YPHHASAIMG HQERLRDQTR
   121  SPKLSHSPQP PSLGDPVEHL SETSADSLEA MSEGDAPTPF SRGSRTRASL PVVRSTNQTK
   181  ERSLGVLYLQ YGDETKQLRM PNEITSADTI RALFVSAFPQ QLTMKMLESP SVAIYIKDES
   241  RNVYYELNDV RNIQDRSLLK VYNKDPAHAF NHTPKTMNGD MRMQRELVYA RGDGPGAPRP
   301  GSTAHPPHAI PNSPPSTPVP HSMPPSPSRI PYGGTRSMVV PGNATIPRDR ISSLPVSRPI
   361  SPSPSAILER RDVKPDEDMS GKNIAMYRNE GFYADPYLYH EGRMSIASSH GGHPLDVPDH
   421  IIAYHRTAIR SASAYCNPSM QAEMHMEQSL YRQKSRKYPD SHLPTLGSKT PPASPHRVSD
   481  LRMIDMHAHY NAHGPPHTMQ PDRASPSRQA FKKEPGTLVY IEKPRSAAGL SSLVDLGPPL
   541  MEKQVFAYST ATIPKDRETR ERMQAMEKQI ASLTGLVQSA LFKGPITSYS KDASSEKMMK
   601  TTANRNHTDS AGTPHVSGGK MLSALESTVP PSQPPPVGTS AIHMSLLEMR RSVAELRLQL
   661  QQMRQLQLQN QELLRAMMKK AELEISGKVM ETMKRLEDPV QRQRVLVEQE RQKYLHEEEK
   721  IVKKLCELED FVEDLKKDST AASRLVTLKD VEDGAFLLRQ VGEAVATLKG EFPTLQNKMR
   781  AILRIEVEAV RFLKEEPHKL DSLLKRVRSM TDVLTMLRRH VTDGLLKGTD AAQAAQYMAM
   841  EKATAAEVLK SQEEAAHTSG QPFHSTGAPG DAKSEVVPLS GMMVRHAQSS PVVIQPSQHS
   901  VALLNPAQNL PHVASSPAVP QEATSTLQMS QAPQSPQIPM NGSAMQSLFI EEIHSVSAKN
   961  RAVSIEKAEK KWEEKRQNLD HYNGKEFEKL LEEAQANIMK SIPNLEMPPA TGPLPRGDAP
  1021  VDKVELSEDS PNSEQDLEKL GGKSPPPPPP PPRRSYLPGS GLTTTRSGDV VYTGRKENIT
  1081  AKASSEDAGP SPQTRATKYP AEEPASAWTP SPPPVTTSSS KDEEEEEEEG DKIMAELQAF
  1141  QKCSFMDVNS NSHAEPSRAD SHVKDTRSGA TVPPKEKKNL EFFHEDVRKS DVEYENGPQM
  1201  EFQKVTTGAV RPSDPPKWER GMENSISDAS RTSEYKTEII MKENSISNMS LLRDSRNYSQ
  1261  ETVPKASFGF SGISPLEDEI NKGSKISGLQ YSIPDTENQT LNYGKTKEME KQNTDKCHVS
  1321  SHTRLTESSV HDFKTEDQEV ITTDFGQVVL RPKEARHANV NPNEDGESSS SSPTEENAAT
  1381  DNIAFMITET TVQVLSSGEV HDIVSQKGED IQTVNIDARK EMTPRQEGTD NEDPVVCLDK
  1441  KPVIIIFDEP MDIRSAYKRL STIFEECDEE LERMMMEEKI EEEEEEENGD SVVQNNNTSQ
  1501  MSHKKVAPGN LRTGQQVETK SQPHSLATET RNPGGQEMNR TELNKFSHVD SPNSECKGED
  1561  ATDDQFESPK KKFKFKFPKK QLAALTQAIR TGTKTGKKTL QVVVYEEEEE DGTLKQHKEA
  1621  KRFEIARSQP EDTPENTVRR QEQPSIESTS PISRTDEIRK NTYRTLDSLE QTIKQLENTI
  1681  SEMSPKALVD TSCSSNRDSV ASSSHIAQEA SPRPLLVPDE GPTALEPPTS IPSASRKGSS
  1741  GAPQTSRMPV PMSAKNRPGT LDKPGKQSKL QDPRQYRQAN GSAKKSGGDF KPTSPSLPAS
  1801  KIPALSPSSG KSSSLPSSSG DSSNLPNPPA TKPSIASNPL SPQTGPPAHS ASLIPSVSNG
  1861  SLKFQSLTHT GKGHHLSFSP QSQNGRAPPP LSFSSSPPSP ASSVSLNQGA KGTRTIHTPS
  1921  LTSYKAQNGS SSKATPSTAK ETS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIAA1217 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 101 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 101 nTPM
tongue: 49 nTPM
parathyroid gland: 39 nTPM
salivary gland: 37 nTPM
thyroid gland: 32 nTPM
esophagus: 29 nTPM

Single-cell type

thymic myoid cells: 4,226 nCPM
myonuclei: 3,978 nCPM
müller glia: 2,401 nCPM
salivary acinar cells: 1,853 nCPM
lacrimal acinar cells: 1,818 nCPM
prostatic club cells: 1,659 nCPM

Immune cell

MAIT T-cell: 0.5 nTPM
NK-cell: 0.2 nTPM
gdT-cell: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

choroid plexus: 127 nTPM
cerebral cortex: 85 nTPM
white matter: 64 nTPM
midbrain: 53 nTPM
basal ganglia: 45 nTPM
medulla oblongata: 42 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.42
gnomAD pLI: 0
gnomAD missense Z: 0.29
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

embryonic skeletal system development

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KIAA1217 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIAA1217 as an antibody target. Whether an autoantibody or antibody against KIAA1217 could matter depends on whether native KIAA1217 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIAA1217 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KIAA1217 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...