Seroatlas · Human Serome Atlas

CORO1A

Coronin-1A

Also known as: COR1A_HUMAN, coronin-1, HCORO1, p57

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P31146
Gene
CORO1A
Ensembl
ENSG00000102879
Chromosome
16
Canonical length
461 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16. [provided by RefSeq, Sep 2010]

Canonical amino-acid sequenceUniProt

461 residues, UniProt reviewed canonical sequence.

>P31146|CORO1A
     1  MSRQVVRSSK FRHVFGQPAK ADQCYEDVRV SQTTWDSGFC AVNPKFVALI CEASGGGAFL
    61  VLPLGKTGRV DKNAPTVCGH TAPVLDIAWC PHNDNVIASG SEDCTVMVWE IPDGGLMLPL
   121  REPVVTLEGH TKRVGIVAWH TTAQNVLLSA GCDNVIMVWD VGTGAAMLTL GPEVHPDTIY
   181  SVDWSRDGGL ICTSCRDKRV RIIEPRKGTV VAEKDRPHEG TRPVRAVFVS EGKILTTGFS
   241  RMSERQVALW DTKHLEEPLS LQELDTSSGV LLPFFDPDTN IVYLCGKGDS SIRYFEITSE
   301  APFLHYLSMF SSKESQRGMG YMPKRGLEVN KCEIARFYKL HERRCEPIAM TVPRKSDLFQ
   361  EDLYPPTAGP DPALTAEEWL GGRDAGPLLI SLKDGYVPPK SRELRVNRGL DTGRRRAAPE
   421  ASGTPSSDAV SRLEEEMRKL QATVQELQKR LDRLEETVQA K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CORO1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
544 nTPM

Expression across tissuesHPA

Tissue

  • lymph node: 544 nTPM
  • bone marrow: 525 nTPM
  • spleen: 360 nTPM
  • tonsil: 289 nTPM
  • appendix: 288 nTPM
  • thymus: 240 nTPM

Single-cell type

  • hofbauer cells: 439 nCPM
  • neutrophils: 378 nCPM
  • nk-cells: 288 nCPM
  • t-cells: 282 nCPM
  • monocytes: 267 nCPM
  • megakaryocytes: 266 nCPM

Immune cell

  • eosinophil: 2,662 nTPM
  • total PBMC: 1,636 nTPM
  • neutrophil: 1,316 nTPM
  • non-classical monocyte: 898 nTPM
  • intermediate monocyte: 856 nTPM
  • T-reg: 856 nTPM

Brain region

  • white matter: 79 nTPM
  • cerebral cortex: 56 nTPM
  • medulla oblongata: 52 nTPM
  • basal ganglia: 50 nTPM
  • spinal cord: 49 nTPM
  • thalamus: 44 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CORO1A.

Disease | AllUniProt

Conditions CORO1A is implicated in, by any mechanism.

  • Immunodeficiency 8 with lymphoproliferation (IMD8) MIM:615401

Disease | GeneticClinVar

19 pathogenic / likely-pathogenic of 386 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Disease | ImmuneIEDB

Conditions an epitope on CORO1A was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.32
gnomAD pLI
0.97
gnomAD missense Z
2.48
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CORO1A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CORO1A as an antibody target. Whether an autoantibody or antibody against CORO1A could matter depends on whether native CORO1A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CORO1A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CORO1A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CORO1A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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