Seroatlas · Human Serome Atlas

RCC2

Protein RCC2

Also known as: RCC2_HUMAN, TD-60

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9P258
Gene
RCC2
Ensembl
ENSG00000179051
Chromosome
1
Canonical length
522 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is a guanine exchange factor that is active on RalA, a small GTPase. The encoded protein and RalA are both essential for proper kinetochore-microtubule function in early mitosis. This protein has been shown to be a biomarker for colorectal cancer. [provided by RefSeq, Oct 2016]

Canonical amino-acid sequenceUniProt

522 residues, UniProt reviewed canonical sequence.

>Q9P258|RCC2
     1  MPRKKAAAAA WEEPSSGNGT ARAGPRKRGG PAGRKRERPE RCSSSSGGGS SGDEDGLELD
    61  GAPGGGKRAA RPATAGKAGG AAVVITEPEH TKERVKLEGS KCKGQLLIFG ATNWDLIGRK
   121  EVPKQQAAYR NLGQNLWGPH RYGCLAGVRV RTVVSGSCAA HSLLITTEGK LWSWGRNEKG
   181  QLGHGDTKRV EAPRLIEGLS HEVIVSAACG RNHTLALTET GSVFAFGENK MGQLGLGNQT
   241  DAVPSPAQIM YNGQPITKMA CGAEFSMIMD CKGNLYSFGC PEYGQLGHNS DGKFIARAQR
   301  IEYDCELVPR RVAIFIEKTK DGQILPVPNV VVRDVACGAN HTLVLDSQKR VFSWGFGGYG
   361  RLGHAEQKDE MVPRLVKLFD FPGRGASQIY AGYTCSFAVS EVGGLFFWGA TNTSRESTMY
   421  PKAVQDLCGW RIRSLACGKS SIIVAADEST ISWGPSPTFG ELGYGDHKPK SSTAAQEVKT
   481  LDGIFSEQVA MGYSHSLVIA RDESETEKEK IKKLPEYNPR TL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RCC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
64 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 64 nTPM
  • skin: 54 nTPM
  • spleen: 38 nTPM
  • salivary gland: 35 nTPM
  • tonsil: 33 nTPM
  • thymus: 32 nTPM

Single-cell type

  • microglia: 87 nCPM
  • oligodendrocyte progenitor cells: 34 nCPM
  • renal collecting duct principal cells: 33 nCPM
  • renal connecting tubule cells: 30 nCPM
  • oligodendrocytes: 28 nCPM
  • papillary tip epithelial cells: 26 nCPM

Immune cell

  • myeloid DC: 3.1 nTPM
  • intermediate monocyte: 2.6 nTPM
  • plasmacytoid DC: 2.5 nTPM
  • non-classical monocyte: 2.1 nTPM
  • classical monocyte: 1.9 nTPM
  • naive B-cell: 1.7 nTPM

Brain region

  • thalamus: 24 nTPM
  • white matter: 23 nTPM
  • medulla oblongata: 20 nTPM
  • spinal cord: 20 nTPM
  • midbrain: 19 nTPM
  • pons: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.33
gnomAD pLI
0.96
gnomAD missense Z
3.09
DepMap mean gene effect
-0.17
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RCC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RCC2 as an antibody target. Whether an autoantibody or antibody against RCC2 could matter depends on whether native RCC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RCC2 is annotated at the cell surface, where native RCC2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RCC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RCC2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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