Seroatlas · Human Serome Atlas

CMTM4

CKLF-like MARVEL transmembrane domain-containing protein 4

Also known as: CKLF4_HUMAN, CKLFSF4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IZR5
Gene: CMTM4
Ensembl: ENSG00000183723
Chromosome: 16
Canonical length: 234 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Golgi apparatus,Vesicles,Plasma membrane

OverviewNCBI Gene

This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

234 residues, UniProt reviewed canonical sequence.

>Q8IZR5|CMTM4
     1  MRSGEELDGF EGEASSTSMI SGASSPYQPT TEPVSQRRGL AGLRCDPDYL RGALGRLKVA
    61  QVILALIAFI CIETIMACSP CEGLYFFEFV SCSAFVVTGV LLIMFSLNLH MRIPQINWNL
   121  TDLVNTGLSA FLFFIASIVL AALNHRAGAE IAAVIFGFLA TAAYAVNTFL AVQKWRVSVR
   181  QQSTNDYIRA RTESRDVDSR PEIQRLDTFS YSTNVTVRKK SPTNLLSLNH WQLA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CMTM4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 36 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 36 nTPM
cerebral cortex: 33 nTPM
hippocampal formation: 32 nTPM
parathyroid gland: 31 nTPM
amygdala: 30 nTPM
stomach: 30 nTPM

Single-cell type

distal convoluted tubule cells: 253 nCPM
renal collecting duct intercalated cells: 230 nCPM
foveolar cells: 226 nCPM
alveolar cells type 1: 221 nCPM
parietal cells: 210 nCPM
renal connecting tubule cells: 205 nCPM

Immune cell

classical monocyte: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM
myeloid DC: 0.1 nTPM
plasmacytoid DC: 0.1 nTPM
basophil: 0 nTPM
eosinophil: 0 nTPM

Brain region

thalamus: 83 nTPM
hippocampal formation: 75 nTPM
midbrain: 74 nTPM
spinal cord: 74 nTPM
medulla oblongata: 74 nTPM
white matter: 71 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.87
gnomAD pLI: 0.23
gnomAD missense Z: 1.15
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CMTM4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CMTM6

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CMTM4 as an antibody target. Whether an autoantibody or antibody against CMTM4 could matter depends on whether native CMTM4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CMTM4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CMTM4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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